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PRKG2 [cytosol]
Stable Identifier
R-HSA-418377
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cGMP-dependent protein kinase 2, KGP2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
cGMP effects (Homo sapiens)
PKG1 phosphorylates BK channels (Homo sapiens)
Cyclic GMP-dependent protein kinases (PKGs) [cytosol] (Homo sapiens)
PRKG2 [cytosol] (Homo sapiens)
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Homo sapiens)
Cyclic GMP-dependent protein kinases (PKGs) [cytosol] (Homo sapiens)
PRKG2 [cytosol] (Homo sapiens)
cGMP stimulates Protein Kinase G (Homo sapiens)
Activated cGMP-dependent protein kinase (PKGs) [cytosol] (Homo sapiens)
Cyclic GMP-dependent protein kinases (PKGs) [cytosol] (Homo sapiens)
PRKG2 [cytosol] (Homo sapiens)
Cyclic GMP-dependent protein kinases (PKGs) [cytosol] (Homo sapiens)
PRKG2 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
PTPS is phosphorylated by cGMP-dependant protein kinase II (Homo sapiens)
PRKG2 [cytosol] (Homo sapiens)
Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Homo sapiens)
PRKG2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
KRAS4B is phosphorylated on serine 181 (Homo sapiens)
PKCZ,PRKG2 [plasma membrane] (Homo sapiens)
PRKG2 dimer:cGMP [cytosol] (Homo sapiens)
PRKG2 dimer [cytosol] (Homo sapiens)
PRKG2 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling (Homo sapiens)
PRKG dimer [cytosol] (Homo sapiens)
PRKG2 dimer [cytosol] (Homo sapiens)
PRKG2 [cytosol] (Homo sapiens)
PRKG homodimer:cGMP [cytosol] (Homo sapiens)
PRKG dimer [cytosol] (Homo sapiens)
PRKG2 dimer [cytosol] (Homo sapiens)
PRKG2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13237 PRKG2
Gene Names
PRKG2, PRKGR2
Chain
initiator methionine:, chain:2-762
Reference Genes
BioGPS Gene:5593 PRKG2
COSMIC (genes):PRKG2 PRKG2
CTD Gene:5593 PRKG2
dbSNP Gene:5593 PRKG2
ENSEMBL:ENSG00000138669 PRKG2
ENSEMBL_homo_sapiens_GENE:ENSG00000138669.10 PRKG2
HGNC:9416 PRKG2
KEGG Gene (Homo sapiens):5593 PRKG2
Monarch:5593 PRKG2
NCBI Gene:5593 PRKG2
OMIM:601591 PRKG2
UCSC:Q13237 PRKG2
Reference Transcript
RefSeq:NM_001282480.1 PRKG2
RefSeq:NM_001282485.1 PRKG2
RefSeq:NM_001282482.1 PRKG2
RefSeq:NM_001282483.1 PRKG2
RefSeq:NM_001282481.1 PRKG2
RefSeq:XM_005263126.3 PRKG2
RefSeq:XM_017008416.1 PRKG2
RefSeq:NM_006259.2 PRKG2
RefSeq:XM_017008415.1 PRKG2
Other Identifiers
11740761_at
11746813_a_at
16977286
207505_PM_at
207505_at
2775210
2775211
2775213
2775215
2775216
2775217
2775218
2775219
2775221
2775223
2775224
2775225
2775226
2775227
2775229
2775230
2775231
2775232
2775233
2775238
2775239
2775240
2775241
2775244
2775245
2775246
33536_at
5593
8101284
A_23_P69663
A_33_P3342598
GE60165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004692
GO:0005524
GO:0005634
GO:0005635
GO:0005829
GO:0005886
GO:0006468
GO:0007165
GO:0016020
GO:0016301
GO:0016310
GO:0016324
GO:0016740
GO:0023052
GO:0030154
GO:0030553
GO:0031965
GO:0032332
GO:0036211
GO:0042802
GO:0043226
GO:0046146
GO:0048856
GO:0051019
GO:0072659
GO:0106310
GO:0140096
GO:1903829
GO:2001226
HMNXSV003012277
ILMN_1804870
PH_hs_0003086
TC04001330.hg
X94612_at
g5453977_3p_at
Participates
as a member of
Cyclic GMP-dependent protein kinases (PKGs) [cytosol] (Homo sapiens)
as a component of
PRKG2 dimer [cytosol] (Homo sapiens)
Inferred To
Dmel\CG4839 [cytosol]
(Drosophila melanogaster)
Homologues of PRKG2 [cytosol]
(Drosophila melanogaster)
PRKG2 [cytosol]
(Bos taurus)
PRKG2 [cytosol]
(Canis familiaris)
PRKG2 [cytosol]
(Drosophila melanogaster)
PRKG2 [cytosol]
(Gallus gallus)
PRKG2 [cytosol]
(Mus musculus)
PRKG2 [cytosol]
(Rattus norvegicus)
PRKG2 [cytosol]
(Sus scrofa)
PRKG2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001269412.1
,
NP_001269411.1
,
NP_001269409.1
,
NP_001269410.1
,
NP_006250.1
,
XP_016863904.1
,
NP_001269414.1
,
XP_016863905.1
,
XP_005263183.1
ZINC - World Drugs
KGP2_HUMAN
Guide to Pharmacology - Targets
1493
OpenTargets
ENSG00000138669
ZINC - FDA approved
KGP2_HUMAN
ZINC - Substances
KGP2_HUMAN
ZINC target
Q13237
ZINC - Biogenic
KGP2_HUMAN
PRO
Q13237
PDB
5C6C
,
5C8W
,
5BV6
,
5JIZ
,
5JIX
,
6BQ8
ZINC - Investigational
KGP2_HUMAN
IntEnz
2.7.11.12
GeneCards
Q13237
HPA
ENSG00000138669-PRKG2
Ensembl
ENSP00000264399
,
ENST00000628926
,
ENSP00000486129
,
ENSG00000138669
,
ENSP00000378945
,
ENST00000264399
,
ENST00000395578
Pharos - Targets
Q13237
ZINC - Predictions - Purchasable
KGP2_HUMAN
HMDB Protein
HMDBP01125
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