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ITPR3 [platelet dense tubular network membrane]
Stable Identifier
R-HSA-418283
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet dense tubular network membrane
Synonyms
Inositol 1,4,5-trisphosphate receptor type 3, ITPR3_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR3 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR3 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR3 [platelet dense tubular network membrane] (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR3 [platelet dense tubular network membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR3 [platelet dense tubular network membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR3 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR3 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR3 [platelet dense tubular network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14573 ITPR3
Gene Names
ITPR3
Chain
chain:1-2671
Reference Genes
BioGPS Gene:3710 ITPR3
COSMIC (genes):ITPR3 ITPR3
CTD Gene:3710 ITPR3
dbSNP Gene:3710 ITPR3
ENSEMBL:ENSG00000096433 ITPR3
ENSEMBL_homo_sapiens_GENE:ENSG00000096433.11 ITPR3
HGNC:6182 ITPR3
KEGG Gene (Homo sapiens):3710 ITPR3
Monarch:3710 ITPR3
NCBI Gene:3710 ITPR3
OMIM:147267 ITPR3
UCSC:Q14573 ITPR3
Reference Transcript
RefSeq:NM_002224.3 ITPR3
Other Identifiers
11742963_at
11742964_a_at
17007543
182_at
201187_PM_s_at
201187_s_at
201188_PM_s_at
201188_s_at
201189_PM_s_at
201189_s_at
239542_PM_at
239542_at
2903783
2903784
2903785
2903795
2903801
2903803
2903804
2903805
2903806
2903807
2903809
2903810
2903811
2903812
2903813
2903814
2903815
2903816
2903817
2903818
2903819
2903820
2903821
2903823
2903825
2903826
2903827
2903829
2903830
2903831
2903832
2903833
2903835
2903836
2903838
2903839
2903842
2903844
2903845
2903846
2903847
2903848
2903849
2903851
2903852
2903853
2903854
2903855
2903857
2903858
2903859
2903860
2903862
2903863
2903864
2903865
2903868
2903871
2903872
2903875
2903877
2903881
2903882
2903883
3710
37343_at
8118734
A_14_P115289
A_14_P133907
A_23_P19517
GE58845
GE85666
GO:0000822
GO:0005215
GO:0005216
GO:0005220
GO:0005262
GO:0005509
GO:0005515
GO:0005634
GO:0005635
GO:0005640
GO:0005654
GO:0005730
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0005903
GO:0006811
GO:0006816
GO:0007186
GO:0007204
GO:0007613
GO:0008289
GO:0008324
GO:0012505
GO:0015278
GO:0016020
GO:0016529
GO:0019722
GO:0023052
GO:0030667
GO:0031095
GO:0031410
GO:0034220
GO:0035091
GO:0043025
GO:0043209
GO:0043226
GO:0043231
GO:0043235
GO:0043533
GO:0045177
GO:0050877
GO:0050909
GO:0050913
GO:0050916
GO:0050917
GO:0051209
GO:0051592
GO:0055065
GO:0055074
GO:0055085
GO:0060291
GO:0070588
GO:0070679
GO:0098554
HMNXSV003038756
HMNXSV003040580
Hs.77515.0.A1_3p_a_at
ILMN_1815500
PH_hs_0004470
TC06000427.hg
U01062_at
g450470_3p_a_at
g4504794_3p_a_at
Participates
as a member of
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
Other forms of this molecule
ITPR3 [endoplasmic reticulum membrane]
Inferred To
itpr3 [platelet dense tubular network membrane]
(Xenopus tropicalis)
ITPR3 [platelet dense tubular network membrane]
(Bos taurus)
ITPR3 [platelet dense tubular network membrane]
(Caenorhabditis elegans)
ITPR3 [platelet dense tubular network membrane]
(Canis familiaris)
ITPR3 [platelet dense tubular network membrane]
(Dictyostelium discoideum)
ITPR3 [platelet dense tubular network membrane]
(Drosophila melanogaster)
ITPR3 [platelet dense tubular network membrane]
(Mus musculus)
ITPR3 [platelet dense tubular network membrane]
(Rattus norvegicus)
ITPR3 [platelet dense tubular network membrane]
(Sus scrofa)
Cross References
RefSeq
NP_002215.2
Guide to Pharmacology - Targets
745
OpenTargets
ENSG00000096433
HPA
ENSG00000096433-ITPR3
GeneCards
Q14573
ZINC target
Q14573
Ensembl
ENST00000605930
,
ENSP00000363435
,
ENSG00000096433
,
ENST00000374316
,
ENSP00000475177
PRO
Q14573
Pharos - Targets
Q14573
HMDB Protein
HMDBP07746
PDB
8TKI
,
6DR2
,
6DRC
,
7T3U
,
6DQS
,
8TKD
,
8TLA
,
7T3R
,
8TKE
,
6DQJ
,
6DQV
,
7T3Q
,
6DR0
,
8TKG
,
8TK8
,
6DRA
,
8TKF
,
6DQN
,
6UQK
,
7T3T
,
7T3P
,
8TL9
,
8TKH
,
6DQZ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92560 BAP1
1
BAP1 [nucleoplasm]
(R-HSA-5689665)
0.64
12
UniProt:Q13507 TRPC3
1
TRPC3(1-848) [plasma membrane]
(R-HSA-426172)
0.591
5
UniProt:P0DTC6 6
4
6 [nuclear envelope]
(R-COV-9727279)
6 [cytosol]
(R-COV-9708916)
6 [endoplasmic reticulum membrane]
(R-COV-9727295)
6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9705293)
0.527
2
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