Reactome | SRC-1 bound to ARRB2 is not activated

SRC-1 bound to ARRB2 is not activated

Stable Identifier

R-HSA-418200

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Src bound to beta-arrestin-2 is not activated

ReviewStatus

5/5

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Activated PAR1 can induce the formation of signalling complexes with a beta-arrestin scaffold. When beta-arrestin-1 is incorporated this leads to Src and subsequent ERK activation. In contrast, complexes containing beta-arrestin-2 do not lead to Src and ERK activation.

Literature References

PubMed ID	Title	Journal	Year
16580177	Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1 Kuo, FT, Fu, HW, Lu, TL	Cell Signal	2006