Reactome | F2R:ARRB1 binds MAPKs, SRC-1

F2R:ARRB1 binds MAPKs, SRC-1

Stable Identifier

R-HSA-418170

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex

ReviewStatus

5/5

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Beta-arrestins can serve as scaffolding molecules that facilitate G-protein independent cell signaling

Literature References

PubMed ID	Title	Journal	Year
9924018	Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes Luttrell, LM, Ferguson, SS, Daaka, Y, Miller, WE, Maudsley, S, Della Rocca, GJ, Lin, F, Kawakatsu, H, Owada, K, Luttrell, DK, Caron, MG, Lefkowitz, RJ	Science	1999
16580177	Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1 Kuo, FT, Lu, TL, Fu, HW	Cell Signal	2006