Reactome | F2R:ARRB1 binds MAPKs, SRC-1

F2R:ARRB1 binds MAPKs, SRC-1

Stable Identifier

R-HSA-418170

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex

ReviewStatus

5/5

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Beta-arrestins can serve as scaffolding molecules that facilitate G-protein independent cell signaling

Literature References

PubMed ID	Title	Journal	Year
9924018	Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes Kawakatsu, H, Luttrell, LM, Ferguson, SS, Owada, K, Caron, MG, Lefkowitz, RJ, Lin, F, Maudsley, S, Miller, WE, Luttrell, DK, Della Rocca, GJ, Daaka, Y	Science	1999
16580177	Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1 Kuo, FT, Fu, HW, Lu, TL	Cell Signal	2006