Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)

Stable Identifier
R-HSA-418163
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Within the beta-arrestin-1:Src:ERK complex, activated Src phosphorylates and activates ERK. ERK activation requires dual Thr and Tyr phosphorylations, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2. Significant ERK activation requires phosphorylation at both sites, with Tyr phosphorylation preceding that of Thr. This reaction is given as a black-box event because the phosphorylation state of ERK on binding to beta-arrestin-1 is unknown.

Literature References
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of F2R:ARRB1:MAPKs:active SRC-1 [plasma membrane]

Orthologous Events
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