Reactome | LPAR6 [plasma membrane]

LPAR6 [plasma membrane]

Stable Identifier

R-HSA-417913

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

P2RY5, P2Y5 receptor, Oleoyl-L-alpha-lysophosphatidic acid receptor, P2RY5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P23458 JAK1

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External Reference Information

External Reference

UniProt:P43657 LPAR6

Gene Names

LPAR6, P2RY5

Chain

chain:1-344

Reference Genes

BioGPS Gene:10161 LPAR6

COSMIC (genes):LPAR6 LPAR6

CTD Gene:10161 LPAR6

dbSNP Gene:10161 LPAR6

ENSEMBL:ENSG00000139679 LPAR6

ENSEMBL_homo_sapiens_GENE:ENSG00000139679.16 LPAR6

HGNC:15520 LPAR6

KEGG Gene (Homo sapiens):10161 LPAR6

Monarch:10161 LPAR6

NCBI Gene:10161 LPAR6

OMIM:609239 LPAR6

UCSC:P43657 LPAR6

Reference Transcript

Other Identifiers

10161

11743071_a_at

16779006

218589_PM_at

218589_at

3513523

3513524

3513525

3513526

3513527

3513528

3513529

3513530

3513531

3513532

3513533

3513534

3513535

3513536

3513537

3513539

3513540

3513541

3513542

3513544

3513545

3513548

75361_r_at

76580_at

7971565

A_23_P2705

GE61767

GO:0001835

GO:0004930

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0007200

GO:0016020

GO:0023052

GO:0035025

GO:0048856

GO:0060089

GO:0070915

HMNXSV003052211

HMNXSV003054382

ILMN_1786429

PH_hs_0022368

g5031968_3p_at

Participates

as an input of

P2Y5 receptor can bind to LPA (Homo sapiens)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

as a component of

P2RY5:LPA [plasma membrane] (Homo sapiens)

Inferred To

lpar6a [plasma membrane] (Danio rerio)

LOC119865171 [plasma membrane] (Canis familiaris)

LPAR6 [plasma membrane] (Bos taurus)

LPAR6 [plasma membrane] (Canis familiaris)

LPAR6 [plasma membrane] (Sus scrofa)

Lpar6 [plasma membrane] (Mus musculus)

Lpar6 [plasma membrane] (Rattus norvegicus)

lpar6 [plasma membrane] (Xenopus tropicalis)

gnrr-4 [plasma membrane] (Caenorhabditis elegans)

Homologues of LPAR6 [plasma membrane] (Canis familiaris)

Cross References

RefSeq

NP_001155969.1, NP_001155970.1, NP_005758.2

Guide to Pharmacology - Targets

163

OpenTargets

ENSG00000139679

ZINC - Substances

LPAR6_HUMAN

ZINC - Biogenic

LPAR6_HUMAN

ZINC target

P43657

PRO

P43657

ZINC - Metabolites

LPAR6_HUMAN

HPA

ENSG00000139679-LPAR6

GeneCards

P43657

Ensembl

ENSP00000344353, ENSG00000139679, ENSP00000367691, ENSP00000482660, ENST00000378434, ENST00000620633, ENST00000345941

Pharos - Targets

P43657

Orphanet

17277

ZINC - Predictions - Purchasable

LPAR6_HUMAN

HMDB Protein

HMDBP07316

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BZL3 SMIM3			0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q6DD88 ATLA3			0.527	2
UniProt:Q68DH5 LMBD2			0.527	2
UniProt:P11532 DMD	1	DMD [cytosol] (R-HSA-390567)	0.527	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.527	2
UniProt:O95858 TSPAN15	2	TSPAN15 [plasma membrane] (R-HSA-9010043) TSPAN15 [endoplasmic reticulum lumen] (R-HSA-9010117)	0.527	2
UniProt:Q8TD22 SFXN5			0.527	2
UniProt:P23458 JAK1	6	p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.527	2
UniProt:Q9BYI3 HYCCI			0.527	2
UniProt:Q96D31 ORAI1	1	ORAI1 [plasma membrane] (R-HSA-434672)	0.527	2
UniProt:Q96QD8 SLC38A2	1	SLC38A2 [plasma membrane] (R-HSA-352093)	0.527	2

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