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COPS8 [cytosol]
Stable Identifier
R-HSA-416962
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
COP9 signalosome complex subunit 8, CSN8_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS8 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
COP9 and TOR1 deneddylate STON2 (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS8 [cytosol] (Homo sapiens)
NEDD8-STONs:TOR1 hexamer:COP9 [cytosol] (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS8 [cytosol] (Homo sapiens)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS8 [cytosol] (Homo sapiens)
NEDD8-STONs:TOR1 hexamer:COP9 [cytosol] (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99627 COPS8
Gene Names
COPS8, CSN8
Chain
initiator methionine:, chain:2-209
Reference Genes
BioGPS Gene:10920 COPS8
COSMIC (genes):COPS8 COPS8
CTD Gene:10920 COPS8
dbSNP Gene:10920 COPS8
ENSEMBL:ENSG00000198612 COPS8
HGNC:24335 COPS8
KEGG:hsa:10920 COPS8
Monarch:10920 COPS8
NCBI Gene:10920 COPS8
OMIM:616011 COPS8
UCSC:Q99627 COPS8
Reference Transcript
RefSeq:NM_198189.2 COPS8
RefSeq:NM_006710.4 COPS8
Other Identifiers
10920
11742682_s_at
11749363_a_at
16892836
202141_PM_s_at
202141_s_at
202142_PM_at
202142_at
202143_PM_s_at
202143_s_at
214260_PM_at
214260_at
236204_PM_at
236204_at
2534132
2534133
2534134
2534137
2534138
2534140
2534144
2534145
2534147
2534148
2534149
2534150
2534151
2534152
2534153
2534154
2534156
2534157
2534158
2534159
2534160
2534161
2534162
2534163
2534164
2534165
2628555
2628556
32539_at
52526_at
8049478
A_14_P130167
A_23_P144257
A_33_P3230324
GE62469
GE861588
GO:0000338
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006468
GO:0007250
GO:0008180
GO:0008285
GO:0010387
GO:0032991
GO:0043226
GO:0043231
GO:0045116
GO:0048471
GO:0065003
GO:0070062
GO:2000434
HMNXSV003014115
Hs.34898.0.A1_3p_at
ILMN_1705711
ILMN_2337941
ILMN_2373779
PH_hs_0030305
PH_hs_0033517
TC02001439.hg
U51205_at
g13111846_3p_a_at
g5729778_3p_a_at
g5729778_3p_x_at
Participates
as a component of
COP9 [cytosol] (Homo sapiens)
Other forms of this molecule
COPS8 [nucleoplasm]
Inferred To
Cops8 [cytosol]
(Mus musculus)
Cops8 [cytosol]
(Rattus norvegicus)
CSN8 [cytosol]
(Drosophila melanogaster)
cops8 [cytosol]
(Danio rerio)
csn8 [cytosol]
(Dictyostelium discoideum)
csn8 [cytosol]
(Xenopus tropicalis)
Ghost homologue of COPS8 [cytosol]
(Caenorhabditis elegans)
COPS8 [cytosol]
(Bos taurus)
COPS8 [cytosol]
(Canis familiaris)
COPS8 [cytosol]
(Gallus gallus)
COPS8 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_937832.1
,
NP_006701.1
ENSEMBL
ENST00000392008
,
ENSP00000375865
,
ENSP00000346340
,
ENST00000354371
OpenTargets
ENSG00000198612
HPA
ENSG00000198612-COPS8
PRO
Q99627
Pharos - Targets
Q99627
GlyGen
Q99627
PDB
6R7I
,
4D10
,
6R6H
,
8H3F
,
6R7N
,
6R7F
,
6R7H
,
4D18
,
4WSN
,
8H38
,
8H3A
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.527
2
UniProt:Q92466 DDB2
3
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
0.527
3
UniProt:P51813 BMX
3
BMX [cytosol]
(R-HSA-351917)
BMX(243-675) [cytosol]
(R-HSA-351875)
BMX(1-242) [cytosol]
(R-HSA-351899)
0.527
2
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.462
6
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