SEMA6D binds to PLXNA1:TREM2:DAP12

Stable Identifier
R-HSA-416725
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Plexin-A1 is a receptor for the transmembrane semaphorin, Sema6D. Plexin-A1 associates with the triggering receptor expressed on myeloid cells-2 (Trem-2), linking semaphorin-signalling to the immuno-receptor tyrosine-based activation motif (ITAM)-bearing adaptor protein, DAP12.

Literature References
PubMed ID Title Journal Year
16715077 Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis

Takamatsu, H, Ikawa, M, Tsujimura, T, Takeda, K, Takegahara, N, Moriya, M, Okabe, M, Sato, S, Terai, K, Okuno, T, Sakoda, S, Nakatsuji, Y, Mizui, M, Yukawa, K, Suzuki, K, Inui, M, Prasad, DV, Ishii, M, Toyofuku, T, Kumanogoh, A, Yamamoto, M, Kikutani, H, Akira, S, Takai, T

Nat Cell Biol 2006
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!