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SEMA4A binds to PLXND1
Stable Identifier
R-HSA-416690
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Other semaphorin interactions (Homo sapiens)
SEMA4A binds to PLXND1 (Homo sapiens)
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Sema4A binds plexinD1 to inhibit angiogenesis. Sema4A–plexinD1 interactions modulate VEGF-mediated endothelial cell migration and proliferation at the intracellular level by suppressing VEGF–VEGFR2-induced activation of Rac1, Akt and integrins.
Literature References
PubMed ID
Title
Journal
Year
17318185
Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1
Yabuki, M
,
Toyofuku, T
,
Kumanogoh, A
,
Kamei, M
,
Hori, M
,
Makino, N
,
Kamei, J
EMBO J
2007
Participants
Input
PLXND1 [plasma membrane]
(Homo sapiens)
SEMA4A [plasma membrane]
(Homo sapiens)
Output
SEMA4A:PLXND1 [plasma membrane]
(Homo sapiens)
Entity On Other Cell
SEMA4A [plasma membrane]
(Homo sapiens)
Participates
as an event of
Other semaphorin interactions (Homo sapiens)
Orthologous Events
SEMA4A binds to PLXND1 (Bos taurus)
SEMA4A binds to PLXND1 (Caenorhabditis elegans)
SEMA4A binds to PLXND1 (Canis familiaris)
SEMA4A binds to PLXND1 (Danio rerio)
SEMA4A binds to PLXND1 (Drosophila melanogaster)
SEMA4A binds to PLXND1 (Gallus gallus)
SEMA4A binds to PLXND1 (Mus musculus)
SEMA4A binds to PLXND1 (Rattus norvegicus)
SEMA4A binds to PLXND1 (Sus scrofa)
Authored
Garapati, P V (2009-03-23)
Reviewed
Kikutani, H (2009-09-02)
Kumanogoh, A (2009-09-02)
Created
Garapati, P V (2009-03-31)
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