SEMA4A binds to PLXND1

Stable Identifier
R-HSA-416690
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Sema4A binds plexinD1 to inhibit angiogenesis. Sema4A–plexinD1 interactions modulate VEGF-mediated endothelial cell migration and proliferation at the intracellular level by suppressing VEGF–VEGFR2-induced activation of Rac1, Akt and integrins.

Literature References
PubMed ID Title Journal Year
17318185 Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1

Toyofuku, T, Yabuki, M, Kamei, J, Kamei, M, Makino, N, Kumanogoh, A, Hori, M

EMBO J 2007
Participants
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Orthologous Events
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Created