SDC2 multimerises

Stable Identifier
R-HSA-4093342
Type
Reaction [omitted]
Species
Homo sapiens
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Syndecan-2 (SDC2), upon phosphorylation by EPHB2, undergoes multimerization and clustering on dendrites leading to spinogenesis. Pathways downstream of SDC2 that ultimately leads to cytoskeletal rearrangement of the spine have yet to be elucidated. Ethell et al. hypothesised that EPHB2 may associate with SDC2 after clustering and localise SDC2 to sites of nascent spines. Subsequent recruitment of syntenin and CASK by SDC2 via PDZ interactions may promote spinogenesis (Ethell et al. 2001, Lin et al. 2007).

Literature References
PubMed ID Title Journal Year
17548511 Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway

Lin, YL, Lei, YT, Hong, CJ, Hsueh, YP

J. Cell Biol. 2007
11580899 EphB/syndecan-2 signaling in dendritic spine morphogenesis

Ethell, IM, Irie, F, Kalo, MS, Couchman, JR, Pasquale, EB, Yamaguchi, Y

Neuron 2001
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