Reactome | SDC2 multimerises

SDC2 multimerises

Stable Identifier

R-HSA-4093342

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Syndecan-2 (SDC2), upon phosphorylation by EPHB2, undergoes multimerization and clustering on dendrites leading to spinogenesis. Pathways downstream of SDC2 that ultimately leads to cytoskeletal rearrangement of the spine have yet to be elucidated. Ethell et al. hypothesised that EPHB2 may associate with SDC2 after clustering and localise SDC2 to sites of nascent spines. Subsequent recruitment of syntenin and CASK by SDC2 via PDZ interactions may promote spinogenesis (Ethell et al. 2001, Lin et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
11580899	EphB/syndecan-2 signaling in dendritic spine morphogenesis Ethell, IM, Irie, F, Kalo, MS, Couchman, JR, Pasquale, EB, Yamaguchi, Y	Neuron	2001
17548511	Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway Lin, YL, Lei, YT, Hong, CJ, Hsueh, YP	J. Cell Biol.	2007