Syndecan-2 (SDC2), upon phosphorylation by EPHB2, undergoes multimerization and clustering on dendrites leading to spinogenesis. Pathways downstream of SDC2 that ultimately leads to cytoskeletal rearrangement of the spine have yet to be elucidated. Ethell et al. hypothesised that EPHB2 may associate with SDC2 after clustering and localise SDC2 to sites of nascent spines. Subsequent recruitment of syntenin and CASK by SDC2 via PDZ interactions may promote spinogenesis (Ethell et al. 2001, Lin et al. 2007).