p-EPHB phosphorylates SDC2

Stable Identifier
R-HSA-4093332
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Syndecans (SDCs) are a major class of cell surface heparan sulphate proteoglycans (HSPGs) and the member syndecan-2 (SDC2) plays a critical role in EPHB-mediated spine formation in hippocampal neurons. Ethell et al. suggest that one of the mechanisms by which EPHB receptors regulate spine morphology is through phosphorylation of SDC2 (Ethell et al. 2001, Ethell & Yamaguchi 1999). Activated EPHB2 phosphorylates SDC2 at tyrosine residues Y189 and Y201 (Y179 and Y191 according to uniprot reference sequence) in the C1 and V regions respectively (Ethell et al. 2001).

Literature References
PubMed ID Title Journal Year
11580899 EphB/syndecan-2 signaling in dendritic spine morphogenesis

Ethell, IM, Irie, F, Kalo, MS, Couchman, JR, Pasquale, EB, Yamaguchi, Y

Neuron 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-EPHB:EFNB oligomers [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!