Reactome | K538-MBD1-G97-SUMO1 [nucleoplasm]

K538-MBD1-G97-SUMO1 [nucleoplasm]

Stable Identifier

R-HSA-4090416

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Small ubiquitin-related modifier 1, SUMO1_HUMAN

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P63165 SUMO1

Gene Names

SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl.43

Chain

initiator methionine:1, chain:2-97, propeptide:98-101

Reference Genes

BioGPS Gene:7341 SUMO1

CTD Gene:7341 SUMO1

dbSNP Gene:7341 SUMO1

ENSEMBL:ENSG00000116030 SUMO1

ENSEMBL_homo_sapiens_GENE:ENSG00000116030 SUMO1

HGNC:12502 SUMO1

KEGG Gene (Homo sapiens):7341 SUMO1

Monarch:7341 SUMO1

NCBI Gene:7341 SUMO1

OMIM:601912 SUMO1

UCSC:P63165 SUMO1

Reference Transcript

Other Identifiers

0006110138

11724205_x_at

11740939_x_at

11744193_x_at

11746828_x_at

11753479_x_at

11763232_x_at

155_s_at

1A5R

1TGZ

1WYW

1Y8R

1Z5S

208761_s_at

208762_at

211069_s_at

2363075

2595254

2595255

2595256

2595257

2595258

2595259

2595260

2595261

2595262

2595264

2595265

2595266

2595274

2ASQ

2BF8

2G4D

2IO2

2IY0

2IY1

2KQS

2LAS

2MW5

2N1A

2N1V

2PE6

2UYZ

2VRR

3838378

3KYC

3KYD

3RZW

3UIP

4269

457_s_at

4WJN

4WJO

4WJP

4WJQ

56956

5AEK

5B7A

5ELJ

5GHD

6EOP

6EOT

7341

8058335

8180373

A0A024R3Z2

A_24_P319354

A_33_P3318459

A_33_P3318465

AAB39999

AAB40388

AAB40390

AAC50733

AAC50996

AAH06462

AAH53528

AAH66306

AAP35278

AAY24035

B8ZZ67

B8ZZJ0

B8ZZN6

B9A032

BAB93477

BAG34782

CAA67898

CAB004269

CAG46944

CAG46953

CCDS2352

CCDS46493

EAW70304

EAW70305

EAW70307

ENSG00000116030

ENSP00000376075

ENSP00000376076

ENSP00000376077

ENST00000392244

ENST00000392245

ENST00000392246

EntrezGene:7341

F8WBI1

g1762972_3p_s_at

g1769601_3p_at

GE59489

GE81266

GO:0000122

GO:0000792

GO:0001222

GO:0001650

GO:0001741

GO:0002376

GO:0003013

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0006259

GO:0006281

GO:0006303

GO:0006355

GO:0006464

GO:0006810

GO:0006950

GO:0007165

GO:0008022

GO:0008076

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0015459

GO:0016020

GO:0016032

GO:0016604

GO:0016605

GO:0016607

GO:0016925

GO:0019789

GO:0019899

GO:0022607

GO:0030425

GO:0030578

GO:0030674

GO:0031334

GO:0031386

GO:0031510

GO:0031625

GO:0031647

GO:0031965

GO:0032436

GO:0032880

GO:0032991

GO:0034605

GO:0034641

GO:0035259

GO:0043226

GO:0043392

GO:0043433

GO:0044388

GO:0044403

GO:0045202

GO:0045759

GO:0045892

GO:0048856

GO:0050821

GO:0055085

GO:0060021

GO:0060334

GO:0061024

GO:0065003

GO:0071276

GO:0086004

GO:0090204

GO:0097165

GO:1901896

GO:1902260

GO:1903169

HGNC:12502

HPA056956

Hs.302113.0.S1_3p_s_at

ILMN_1790105

ILMN_2379835

IPR000626

IPR022617

IPR029071

IPR033950

MIM:601912

MIM:613705

NM_001005781

NM_001005782

NM_003352

NP_001005781

NP_001005782

NP_003343

PF11976

PH_hs_0029007

SM00213

SUMO1

SUMO1-201

SUMO1-202

SUMO1-203

TC02002682.hg

U61397_s_at

U67122_s_at

uc002uyz.2

uc002uza.2

uc061rmp.1

UPI0000001227

UPI00002093D7

X99586_s_at

Participant Of

hasComponent

2SUMO1:MBD1 [nucleoplasm]

Other forms of this molecule

K14-UBE2I-G97-SUMO1 [nucleoplasm]

TOPORS-G97-SUMO1 [nucleoplasm]

PIAS4-G97-SUMO1 [nucleoplasm]

K2592-RANBP2-G97-SUMO1 [nuclear envelope]

K2723-RANBP2-G97-SUMO1 [nuclear envelope]

K2650-RANBP2-G97-SUMO1 [nuclear envelope]

K196-VHL-G97-SUMO1 [nucleoplasm]

K171-VHL-G97-SUMO1 [nucleoplasm]

K159-VHL-G97-SUMO1 [nucleoplasm]

MDM-G97-SUMO1 [nucleoplasm]

K575-TRIM28-G97-SUMO1 [nucleoplasm]

K804-TRIM28-G97-SUMO1 [nucleoplasm]

K750-TRIM28-G97-SUMO1 [nucleoplasm]

K676-TRIM28-G97-SUMO1 [nucleoplasm]

K554-TRIM28-G97-SUMO1 [nucleoplasm]

K779-TRIM28-G97-SUMO1 [nucleoplasm]

ING2-G97-SUMO1 [nucleoplasm]

K788-Ncoa2-G97-SUMO1 [nucleoplasm]

K731-Ncoa2-G97-SUMO1 [nucleoplasm]

K239-Ncoa2-G97-SUMO1 [nucleoplasm]

K239-NCOA2-G97-SUMO1 [nucleoplasm]

K731-NCOA2-G97-SUMO1 [nucleoplasm]

K788-NCOA2-G97-SUMO1 [nucleoplasm]

NPM1-G97-SUMO1 [nucleoplasm]

NCOR2-G97-SUMO1 [nucleoplasm]

DDX17-G97-SUMO1 [nucleoplasm]

PARK7-G97-SUMO1 [nucleoplasm]

K1033-CREBBP-G97-SUMO1 [nucleoplasm]

K1056-CREBBP-G97-SUMO1 [nucleoplasm]

K998-CREBBP-G97-SUMO1 [nucleoplasm]

K1154-NRIP1-G97-SUMO1 [nucleoplasm]

K756-NRIP1-G97-SUMO1 [nucleoplasm]

DDX5-G97-SUMO1 [nucleoplasm]

CASP8AP2-G97-SUMO1 [nucleoplasm]

K1024-EP300-G97-SUMO1 [nucleoplasm]

K1020-EP300-G97-SUMO1 [nucleoplasm]

CTBP1-G97-SUMO1 [nucleoplasm]

K231-SAFB-G97-SUMO1 [nucleoplasm]

K294-SAFB-G97-SUMO1 [nucleoplasm]

K624-MKL1-G97-SUMO1 [nucleoplasm]

K576-MKL1-G97-SUMO1 [nucleoplasm]

K499-MKL1-G97-SUMO1 [nucleoplasm]

K631-DAXX-G97-SUMO1 [nucleoplasm]

K630-DAXX-G97-SUMO1 [nucleoplasm]

SIN3A-G97-SUMO1 [nucleoplasm]

PPARGC1A-G97-SUMO1 [nucleoplasm]

HIPK2-G97-SUMO1 [nucleoplasm]

K774-NCOA1-G97-SUMO1 [nucleoplasm]

K732-NCOA1-G97-SUMO1 [nucleoplasm]

K499-MBD1-G97-SUMO1 [nucleoplasm]

ZNF131-G97-SUMO1 [nucleoplasm]

K90-NFKB2-G97-SUMO1 [cytosol]

K689-NFKB2-G97-SUMO1 [cytosol]

K863-NFKB2-G97-SUMO1 [cytosol]

K298-NFKB2-G97-SUMO1 [cytosol]

UBE2I-G97-SUMO1 [cytosol]

p-S172-IKBKE-G97-SUMO1 [nucleoplasm]

K309-IKBKG-G97-SUMO1 [nucleoplasm]

K277-IKBKG-G97-SUMO1 [nucleoplasm]

NFKBIA-G97-SUMO1 [nucleoplasm]

RANGAP1-G97-SUMO1 [nucleoplasm]

AURKA-G97-SUMO1 [cytosol]

TOP2B-G97-SUMO1 [nucleoplasm]

TOP1-G97-SUMO1 [nucleoplasm]

TOP2A-G97-SUMO1 [nucleoplasm]

K254-PCNA-G97-SUMO1 [nucleoplasm]

K-PCNA-G97-SUMO1 [nucleoplasm]

K164-PCNA-G97-SUMO1 [nucleoplasm]

MDC1-G97-SUMO1 [nucleoplasm]

STAG2-G97-SUMO1 [nucleoplasm]

RAD21-G97-SUMO1 [nucleoplasm]

K411-RAD52-G97-SUMO1 [nucleoplasm]

K412-RAD52-G97-SUMO1 [nucleoplasm]

K414-RAD52-G97-SUMO1 [nucleoplasm]

XRCC4-G97-SUMO1 [nucleoplasm]

K160-PML-G97-SUMO1 [nucleoplasm]

K490-PML-G97-SUMO1 [nucleoplasm]

K65-PML-G97-SUMO1 [nucleoplasm]

K203-PARP1-G97-SUMO1 [nucleoplasm]

K486-PARP1-G97-SUMO1 [nucleoplasm]

K496-WRN-G97-SUMO1 [nucleoplasm]

K898-WRN-G97-SUMO1 [nucleoplasm]

K356-WRN-G97-SUMO1 [nucleoplasm]

RNF168-SUMO1 [nucleoplasm]

XPC-G97-SUMO1 [nucleoplasm]

TDG-G97-SUMO1 [nucleoplasm]

SP100-G97-SUMO1 [nucleoplasm]

BRCA1-G97-SUMO1 [nucleoplasm]

RXRA-G97-SUMO1 [nucleoplasm]

NR5A2-G97-SUMO1 [nucleoplasm]

K386-AR-G97-SUMO1 [nucleoplasm]

K520-AR-G97-SUMO1 [nucleoplasm]

K293-NR3C1-G97-SUMO1 [nucleoplasm]

K277-NR3C1-G97-SUMO1 [nucleoplasm]

K389-THRA-G97-SUMO1 [nucleoplasm]

K283-THRA-G97-SUMO1 [nucleoplasm]

K399-NR3C2-G97-SUMO1 [nucleoplasm]

K428-NR3C2-G97-SUMO1 [nucleoplasm]

K494-NR3C2-G97-SUMO1 [nucleoplasm]

K89-NR3C2-G97-SUMO1 [nucleoplasm]

K119-NR5A1-G97-SUMO1 [nucleoplasm]

K194-NR5A1-G97-SUMO1 [nucleoplasm]

NR2C1-G97-SUMO1 [nucleoplasm]

K303-ESR1-G97-SUMO1 [nucleoplasm]

K266-ESR1-G97-SUMO1 [nucleoplasm]

K302-ESR1-G97-SUMO1 [nucleoplasm]

K299-ESR1-G97-SUMO1 [nucleoplasm]

K268-ESR1-G97-SUMO1 [nucleoplasm]

K531-PGR-G97-SUMO1 [nucleoplasm]

K7-PGR-G97-SUMO1 [nucleoplasm]

K388-PGR-G97-SUMO1 [nucleoplasm]

K132-NR1H4-G97-SUMO1 [nucleoplasm]

NR1H4-G97-SUMO1 [nucleoplasm]

PPARG-G97-SUMO1 [nucleoplasm]

K395-PPARG-G97-SUMO1 [nucleoplasm]

PPARA-G97-SUMO1 [nucleoplasm]

K443-THRB-G97-SUMO1 [nucleoplasm]

K146-THRB-G97-SUMO1 [nucleoplasm]

K50-THRB-G97-SUMO1 [nucleoplasm]

RORA-G97-SUMO1 [nucleoplasm]

HIC1-G97-SUMO1 [nucleoplasm]

TP53BP1-G97-SUMO1 [nucleoplasm]

SP3-G97-SUMO1 [nucleoplasm]

K423-MITF-G97-SUMO1 [nucleoplasm]

K289-MITF-G97-SUMO1 [nucleoplasm]

K25-FOXL2-G97-SUMO1 [nucleoplasm]

K150-FOXL2-G97-SUMO1 [nucleoplasm]

K114-FOXL2-G97-SUMO1 [nucleoplasm]

HNRNPC-G97-SUMO1 [nucleoplasm]

K497-NOP58-G97-SUMO1 [nucleoplasm]

K467-NOP58-G97-SUMO1 [nucleoplasm]

DNMT3B-G97-SUMO1 [nucleoplasm]

DNMT3A-G97-SUMO1 [nucleoplasm]

DNMT1-G97-SUMO1 [nucleoplasm]

K84-CBX5-G97-SUMO1 [nucleoplasm]

K-CBX5-G97-SUMO1 [nucleoplasm]

K476-HDAC1-G97-SUMO1 [nucleoplasm]

K444-HDAC1-G97-SUMO1 [nucleoplasm]

CBX4-G97-SUMO1 [nucleoplasm]

HDAC2-G97-SUMO1 [nucleoplasm]

SUZ12-G97-SUMO1 [nucleoplasm]

SATB1-G97-SUMO1 [nucleoplasm]

HDAC4-G97-SUMO1 [nucleoplasm]

K1971-CHD3-G97-SUMO1 [nucleoplasm]

HIST1H4-G97-SUMO1 [nucleoplasm]

BMI1-G97-SUMO1 [nucleoplasm]

TFAP2B-G97-SUMO1 [nucleoplasm]

TFAP2C-G97-SUMO1 [nucleoplasm]

TFAP2A-1-G97-SUMO1 [nucleoplasm]

SUMO1(2-101) [nucleoplasm]

SUMO1 [nucleoplasm]

UBA2-G97-SUMO1 [nucleoplasm]

UBE2I-G97-SUMO1 [nucleoplasm]

HERC2-SUMO1 [nucleoplasm]

Inferred To

K499-MBD1-G97-SUMO1 [nucleoplasm] (Bos taurus)

K499-MBD1-G97-SUMO1 [nucleoplasm] (Canis familiaris)

K499-MBD1-G97-SUMO1 [nucleoplasm] (Danio rerio)

K499-MBD1-G97-SUMO1 [nucleoplasm] (Mus musculus)

K499-MBD1-G97-SUMO1 [nucleoplasm] (Rattus norvegicus)

K499-MBD1-G97-SUMO1 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

Inter-chain Crosslink via sumoylated lysine at 97 and 538

Coordinate

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001005781.1, NP_003343.1, NP_001005782.1

OpenTargets

ENSG00000116030

GeneCards

P63165

DOCK Blaster

2IY1, 5ELJ, 2UYZ, 4WJQ, 5AEK, 4WJP, 2IO2, 1WYW, 4WJN, 2BF8, 1TGZ, 3KYC, 1Z5S, 3UIP, 4WJO, 3KYD, 2PE6, 1Y8R, 2VRR, 2G4D, 2IY0, 3RZW

PRO

P63165

BRENDA (Homo sapiens)

2.3.2, 2.3.1.48, 2.1.2

Orphanet

16822

PDB

2IO2, 2G4D, 5B7A, 4WJO, 3KYD, 6EOT, 4WJP, 2IY1, 2N1V, 2KQS, 3RZW, 5AEK, 2ASQ, 5GHD, 3KYC, 3UIP, 2IY0, 6EOP, 4WJN, 2UYZ, 1Y8R, 1WYW, 1A5R, 2N1A, 2MW5, 1TGZ, 5ELJ, 1Z5S, 2BF8, 4WJQ, 2PE6, 2LAS, 2VRR

Interactors (71)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) SUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.957	13
UniProt:P63279 UBE2I	8	SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) UBE2I [cytosol] (R-HSA-4655342) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617)	0.946	10
UniProt:Q9P0U3 SENP1	1	SENP1 [nucleoplasm] (R-HSA-2984299)	0.865	9
UniProt:P29590 PML	5	SUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) SUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) SUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.832	6
UniProt:Q9UBT2 UBA2	4	SUMO2-C173-UBA2 [nucleoplasm] (R-HSA-3730612) SUMO3-C173-UBA2 [nucleoplasm] (R-HSA-3730623) SUMO1-C173-UBA2 [nucleoplasm] (R-HSA-3730628) UBA2 [nucleoplasm] (R-HSA-947696)	0.795	7
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.783	7
UniProt:P23497 SP100	3	SUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) SP100 [nucleoplasm] (R-HSA-1031705)	0.764	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.722	3
UniProt:Q6PEW1 ZCH12			0.718	6
UniProt:Q9Y4B4 ARIP4			0.696	5
UniProt:Q7KZS0 Q7KZS0			0.696	5
UniProt:Q96B23 CR025			0.696	5
UniProt:Q9HCK0 ZBT26			0.696	5
UniProt:P15336 ATF2	2	ATF2 [nucleoplasm] (R-HSA-450336) p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243)	0.696	5
UniProt:P07910 HNRNPC	2	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543)	0.696	5
UniProt:Q16665 HIF1A	6	2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.688	4
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.666	6
UniProt:Q9UBE0 SAE1	1	SAE1 [nucleoplasm] (R-HSA-947697)	0.656	3
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.656	5
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.623	2
UniProt:Q5W0Q7 USPL1			0.611	5
UniProt:P38398 BRCA1	5	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) BRCA1 [nucleoplasm] (R-HSA-50949) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.602	3
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.602	7
UniProt:Q9UBC3 DNMT3B	2	DNMT3B [nucleoplasm] (R-HSA-212316) SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334)	0.59	4
UniProt:Q9ERU9 Ranbp2	5	SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-MMU-4551599) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-5228524) RANBP2 [nuclear envelope] (R-MMU-2993756) RANBP2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.564	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.564	3
UniProt:Q9BPY3 F118B			0.556	3
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:Q59GP6 Q59GP6			0.556	3
UniProt:Q12800 TFCP2			0.556	3
UniProt:Q15916 ZBTB6			0.556	3
UniProt:Q9UJ78 ZMYM5			0.556	3
UniProt:A0A0S2Z4M1 A0A0S2Z4M1			0.556	6
UniProt:A0A0S2Z3N6 A0A0S2Z3N6			0.556	3
UniProt:Q8NDC0 MISSL			0.556	3
UniProt:Q9BQY4 RHXF2			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:O95073 FSBP			0.556	3
UniProt:Q05D60 DEUP1			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:Q8TES7-6 FBF1			0.556	3
UniProt:P10276 RARA	3	SUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) RARA [nucleoplasm] (R-HSA-446164)	0.556	5
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.556	3
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) p-T231-CARD9 [plasma membrane] (R-HSA-5607623) CARD9 [plasma membrane] (R-HSA-5607662)	0.556	3
UniProt:Q8WWZ3 EDARADD	1	EDARADD [cytosol] (R-HSA-5675659)	0.556	5
UniProt:O14964 HGS	1	HGS [cytosol] (R-HSA-182954)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040)	0.556	3
UniProt:O00180 KCNK1	1	KCNK1 [plasma membrane] (R-HSA-1296345)	0.544	3
UniProt:Q02078-1 MEF2A			0.544	3
UniProt:P59595 NCAP			0.544	2
UniProt:P10242 MYB	1	MYB [nucleoplasm] (R-HSA-992697)	0.544	3
UniProt:P10914 IRF1	2	IRF1 [cytosol] (R-HSA-1015686) IRF1 [nucleoplasm] (R-HSA-983456)	0.544	2
UniProt:Q9H2X6 HIPK2	3	p-HIPK2 [nucleoplasm] (R-HSA-6799375) SUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405) HIPK2 [nucleoplasm] (R-HSA-3215222)	0.544	2
UniProt:P06748-1 NPM1			0.524	3
UniProt:Q9UIS9 MBD1	2	MBD1 [nucleoplasm] (R-HSA-417134) SUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331)	0.524	3
UniProt:Q01826 SATB1	5	SUMO1-K744-SATB1 [nucleoplasm] (R-HSA-4615954) SUMO2,3-K744-SATB1 [nucleoplasm] (R-HSA-4615978) SATB1(255-763) [nucleoplasm] (R-HSA-352264) SATB1(1-254) [nucleoplasm] (R-HSA-352269) SATB1 [nucleoplasm] (R-HSA-201593)	0.508	2
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.499	2
UniProt:Q9Y2F9 BTBD3			0.488	2
UniProt:P78317 RNF4	2	RNF4 [cytosol] (R-HSA-975974) RNF4 [nucleoplasm] (R-HSA-5684076)	0.488	2
UniProt:Q8N3Z6 ZCHC7			0.488	2
UniProt:P23497-2 SP100			0.488	2
IntAct:EBI-11954883 TMIE			0.488	2
UniProt:Q8N680 ZBTB2			0.488	2
UniProt:O00463 TRAF5			0.488	2
UniProt:Q96MM3 ZFP42			0.488	2
UniProt:O75360 PROP1			0.488	2
UniProt:P0C206 REX			0.488	2
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.488	2
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.488	2