PDE6 hydrolyses cGMP to GMP

Stable Identifier
Reaction [transition]
Homo sapiens
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WNT signaling through WNT5A and FZD2 leads to a decrease in intracellular cGMP levels in a manner that is dependent on G alpha t2 and PDE6 (Ahumada et al, 2002; Ma and Wang, 2006; Ma and Wang, 2007, Bazhin et al, 2010). In response to decreasing cGMP levels, the activity of cGMP-dependent protein kinase G (PKG) also decreases, and this reduction in PKG activity is required both for intracellular calcium release and for activation of NFAT-dependent transcription in response to WNT5A (Ma and Wang, 2006).

Literature References
PubMed ID Title Journal Year
12471263 Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP

Ahumada, A, Slusarski, DC, Liu, X, Moon, RT, Malbon, CC, Wang, HY

Science 2002
17684012 Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway

Ma, L, Wang, HY

J. Biol. Chem. 2007
16920709 Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway

Ma, L, Wang, HY

J. Biol. Chem. 2006
19946729 cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells

Bazhin, AV, Tambor, V, Dikov, B, Philippov, PP, Schadendorf, D, Eichm├╝ller, SB

Cell. Mol. Life Sci. 2010
Participant Of
Catalyst Activity
Catalyst Activity
3',5'-cyclic-GMP phosphodiesterase activity of GNAT2:PDE6 [plasma membrane]
Physical Entity
Orthologous Events
Cross References
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