WNT signaling through WNT5A and FZD2 leads to a decrease in intracellular cGMP levels in a manner that is dependent on G alpha t2 and PDE6 (Ahumada et al, 2002; Ma and Wang, 2006; Ma and Wang, 2007, Bazhin et al, 2010). In response to decreasing cGMP levels, the activity of cGMP-dependent protein kinase G (PKG) also decreases, and this reduction in PKG activity is required both for intracellular calcium release and for activation of NFAT-dependent transcription in response to WNT5A (Ma and Wang, 2006).
Wang, HY, Ma, L
Wang, HY, Liu, X, Slusarski, DC, Malbon, CC, Ahumada, A, Moon, RT
Eichmüller, SB, Philippov, PP, Schadendorf, D, Tambor, V, Bazhin, AV, Dikov, B
3',5'-cyclic-GMP phosphodiesterase activity of GNAT2:PDE6 [plasma membrane]
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