Reactome | PDE6 hydrolyses cGMP to GMP

PDE6 hydrolyses cGMP to GMP

Stable Identifier

R-HSA-4086392

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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WNT signaling through WNT5A and FZD2 leads to a decrease in intracellular cGMP levels in a manner that is dependent on G alpha t2 and PDE6 (Ahumada et al, 2002; Ma and Wang, 2006; Ma and Wang, 2007). In response to decreasing cGMP levels, the activity of cGMP-dependent protein kinase G (PKG) also decreases, and this reduction in PKG activity is required both for intracellular calcium release and for activation of NFAT-dependent transcription in response to WNT5A (Ma and Wang, 2006).

Literature References

PubMed ID	Title	Journal	Year
17684012	Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway Wang, HY, Ma, L	J. Biol. Chem.	2007
12471263	Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP Wang, HY, Liu, X, Slusarski, DC, Malbon, CC, Ahumada, A, Moon, RT	Science	2002
16920709	Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway Wang, HY, Ma, L	J. Biol. Chem.	2006