Reactome | PDE6 hydrolyses cGMP to GMP

PDE6 hydrolyses cGMP to GMP

Stable Identifier

R-HSA-4086392

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

WNT signaling through WNT5A and FZD2 leads to a decrease in intracellular cGMP levels in a manner that is dependent on G alpha t2 and PDE6 (Ahumada et al, 2002; Ma and Wang, 2006; Ma and Wang, 2007). In response to decreasing cGMP levels, the activity of cGMP-dependent protein kinase G (PKG) also decreases, and this reduction in PKG activity is required both for intracellular calcium release and for activation of NFAT-dependent transcription in response to WNT5A (Ma and Wang, 2006).

Literature References

PubMed ID	Title	Journal	Year
17684012	Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway Ma, L, Wang, HY	J. Biol. Chem.	2007
12471263	Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP Ahumada, A, Slusarski, DC, Liu, X, Moon, RT, Malbon, CC, Wang, HY	Science	2002
16920709	Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway Ma, L, Wang, HY	J. Biol. Chem.	2006