Reactome | ST8SIA1 [Golgi membrane]

ST8SIA1 [Golgi membrane]

Stable Identifier

R-HSA-4086283

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase ecNumber2.4.99.8/ecNumber, SIA8A_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)
        
        ST8SIA1-6 [Golgi membrane] (Homo sapiens)
        
        ST8SIA1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92185 ST8SIA1

Gene Names

ST8SIA1, SIAT8, SIAT8A

Chain

chain:1-356

Reference Genes

BioGPS Gene:6489 ST8SIA1

COSMIC (genes):ST8SIA1 ST8SIA1

CTD Gene:6489 ST8SIA1

dbSNP Gene:6489 ST8SIA1

ENSEMBL:ENSG00000111728 ST8SIA1

HGNC:10869 ST8SIA1

KEGG:hsa:6489 ST8SIA1

Monarch:6489 ST8SIA1

NCBI Gene:6489 ST8SIA1

OMIM:601123 ST8SIA1

UCSC:Q92185 ST8SIA1

Reference Transcript

Other Identifiers

11715292_at

1569788_PM_at

1569788_at

210073_PM_at

210073_at

3447023

3447024

3447025

3447026

3447027

3447028

3447030

3447033

3447035

3447041

3447042

3447043

3447044

3447045

3447046

3447047

3447049

3447055

3447056

3447057

3447059

3447060

3447063

3447068

3447075

3447087

3447088

3447089

3447090

3447099

3447100

3447101

3447102

3447103

3447105

3447107

3447108

3447109

40678_at

50035_at

6489

7961755

7961757

A_23_P354705

A_33_P3380751

GE60035

GE800081

GO:0000139

GO:0003824

GO:0003828

GO:0005515

GO:0005794

GO:0005975

GO:0006486

GO:0006491

GO:0006629

GO:0006665

GO:0006688

GO:0008283

GO:0008373

GO:0009311

GO:0016020

GO:0016740

GO:0016757

GO:0034605

GO:0043226

GO:0050673

GO:0050679

GO:1901135

HMNXSV003018166

HMNXSV003023147

HMNXSV003054498

Hs2.134825.1.S1_3p_at

ILMN_1664859

ILMN_2048011

PH_hs_0024758

TC12001301.hg

TC12002790.hg

TC12002791.hg

X77922_s_at

g662253_3p_at

Participates

as a member of

ST8SIA1-6 [Golgi membrane] (Homo sapiens)

Inferred To

Sial-T2 [Golgi membrane] (Gallus gallus)

ST8SIA1 [Golgi membrane] (Bos taurus)

ST8SIA1 [Golgi membrane] (Canis familiaris)

ST8SIA1 [Golgi membrane] (Sus scrofa)

St8sia1 [Golgi membrane] (Mus musculus)

St8sia1 [Golgi membrane] (Rattus norvegicus)

st8sia1 [Golgi membrane] (Danio rerio)

st8sia1 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003025.1, NP_001291379.1

ENSEMBL

ENSP00000379353, ENSG00000111728, ENST00000396037, ENST00000261197, ENSP00000261197

OpenTargets

ENSG00000111728

GeneCards

ST8SIA1

HPA

ENSG00000111728-ST8SIA1

PRO

Q92185

Pharos - Targets

Q92185

GlyGen

Q92185

HMDB Protein

HMDBP00271

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3