Reactome | OPN (osteopontin) degradation by MMP3, MMP7

OPN (osteopontin) degradation by MMP3, MMP7

Stable Identifier

R-HSA-4086205

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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OPN (osteopontin) degradation by MMP3, MMP7

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OPN is a substrate for MMP3 and MMP7. Three cleavage sites were identified, Gly166-Leu167, Ala201-Tyr202 (MMP-3 only), and Asp210-Leu211. The resulting OPN fragments facilitate adhesion and migration in vitro through activation of beta1-containing integrins (Agnihotri et al. 2001). OPN has also been shown to be a substrate for liver transglutaminase and plasma transglutaminase factor IIIa, resulting in protein crosslinking (Prince et al. 1991), enhanced cell adhesion, spreading, focal contact formation and migration

Literature References

PubMed ID	Title	Journal	Year
11375993	Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin) Haro, H, Agnihotri, R, Havrda, MC, Liaw, L, Crawford, HC, Matrisian, LM	J. Biol. Chem.	2001