Reactome | NANP [cytosol]

NANP [cytosol]

Stable Identifier

R-HSA-4085391

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

N-acylneuraminate-9-phosphatase ecNumber3.1.3.29/ecNumber, NANP_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)
        
        NANP:Mg2+ [cytosol] (Homo sapiens)
        
        NANP [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TBE9 NANP

Gene Names

NANP, C20orf147, HDHD4

Chain

chain:1-248

Reference Genes

BioGPS Gene:140838 NANP

COSMIC (genes):NANP NANP

CTD Gene:140838 NANP

dbSNP Gene:140838 NANP

ENSEMBL:ENSG00000170191 NANP

ENSEMBL_homo_sapiens_GENE:ENSG00000170191.5 NANP

HGNC:16140 NANP

KEGG Gene (Homo sapiens):140838 NANP

Monarch:140838 NANP

NCBI Gene:140838 NANP

OMIM:610763 NANP

UCSC:Q8TBE9 NANP

Reference Transcript

RefSeq:NM_152667.2 NANP

Other Identifiers

11736270_at

11736271_at

11758497_s_at

140838

16918132

228073_PM_at

228073_at

3902055

3902056

3902057

3902060

3902061

60323_at

77008_at

8065510

A_23_P427039

A_24_P348428

A_33_P3406458

GE576551

GO:0003824

GO:0005575

GO:0005829

GO:0005975

GO:0006045

GO:0016311

GO:0016787

GO:0046380

GO:0050124

GO:1901135

HMNXSV003033921

Hs.143137.0.A1_3p_at

ILMN_1667132

ILMN_2064132

PH_hs_0008421

TC20000734.hg

Participates

as a component of

NANP:Mg2+ [cytosol] (Homo sapiens)

Inferred To

NANP [cytosol] (Bos taurus)

NANP [cytosol] (Canis familiaris)

NANP [cytosol] (Gallus gallus)

NANP [cytosol] (Mus musculus)

NANP [cytosol] (Rattus norvegicus)

NANP [cytosol] (Sus scrofa)

Dmel\CG15771 [cytosol] (Drosophila melanogaster)

zgc:111947 [cytosol] (Danio rerio)

nanp [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_689880.1

OpenTargets

ENSG00000170191

IntEnz

3.1.3.29

GeneCards

Q8TBE9

HPA

ENSG00000170191-NANP

Ensembl

ENST00000304788, ENSP00000302441, ENSG00000170191

ZINC target

Q8TBE9

PRO

Q8TBE9

Pharos - Targets

Q8TBE9

HMDB Protein

HMDBP07356

PDB

4KNV, 2W4M, 4KNW

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