Reactome | Tumstatin binds integrin alphaVbeta 3, alpha3beta1

Tumstatin binds integrin alphaVbeta 3, alpha3beta1

Stable Identifier

R-HSA-4085083

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

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Tumstatin binds integrin alphaVbeta 3, alpha3beta1

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Tumstatin, the non collagenous C-teminal domain of alpha-3(IV) collagen, binds to integrin alpha V beta 3 (Sudhakar et al. 2003) and alpha3beta1 (Borza et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12682293	Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins Sudhakar, A, Sugimoto, H, Yang, C, Lively, J, Zeisberg, M, Kalluri, R	Proc. Natl. Acad. Sci. U.S.A.	2003
16731529	Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3 Borza, CM, Pozzi, A, Borza, DB, Pedchenko, V, Hellmark, T, Hudson, BG, Zent, R	J. Biol. Chem.	2006