Tumstatin binds integrin alphaVbeta 3, alpha3beta1

Stable Identifier
R-HSA-4085083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Tumstatin binds integrin alphaVbeta 3, alpha3beta1
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Tumstatin, the non collagenous C-teminal domain of alpha-3(IV) collagen, binds to integrin alpha V beta 3 (Sudhakar et al. 2003) and alpha3beta1 (Borza et al. 2006).
Literature References
PubMed ID Title Journal Year
16731529 Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3

Borza, CM, Pozzi, A, Borza, DB, Pedchenko, V, Hellmark, T, Hudson, BG, Zent, R

J. Biol. Chem. 2006
12682293 Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins

Sudhakar, A, Sugimoto, H, Yang, C, Lively, J, Zeisberg, M, Kalluri, R

Proc. Natl. Acad. Sci. U.S.A. 2003
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Orthologous Events
Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Caenorhabditis elegans)
Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Danio rerio)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-08-01)
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