Tumstatin binds integrin alphaVbeta 3, alpha3beta1

Stable Identifier
R-HSA-4085083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Tumstatin binds integrin alphaVbeta 3, alpha3beta1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Tumstatin, the non collagenous C-teminal domain of alpha-3(IV) collagen, binds to integrin alpha V beta 3 (Sudhakar et al. 2003) and alpha3beta1 (Borza et al. 2006).
Literature References
PubMed ID Title Journal Year
16731529 Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3

Hudson, BG, Borza, DB, Zent, R, Borza, CM, Hellmark, T, Pozzi, A, Pedchenko, V

J. Biol. Chem. 2006
12682293 Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins

Sudhakar, A, Yang, C, Lively, J, Kalluri, R, Sugimoto, H, Zeisberg, M

Proc. Natl. Acad. Sci. U.S.A. 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Bos taurus)
Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Canis familiaris)
Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Mus musculus)
Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Rattus norvegicus)
Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Sus scrofa)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-08-01)
Cite Us!