Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
3x4Hyp-3Hyp-COL4A2(1486-1712) [extracellular region]
Stable Identifier
R-HSA-4085048
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Homo sapiens)
Canstatin [extracellular region] (Homo sapiens)
3x4Hyp-3Hyp-COL4A2(1486-1712) [extracellular region] (Homo sapiens)
Canstatin:Integrins alphaVbeta3, alphaVbeta5 [plasma membrane] (Homo sapiens)
Canstatin [extracellular region] (Homo sapiens)
3x4Hyp-3Hyp-COL4A2(1486-1712) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08572 COL4A2
Gene Names
COL4A2
Chain
signal peptide:1-25, propeptide:26-183, chain:184-1712, chain:1486-1712
Reference Genes
BioGPS Gene:1284 COL4A2
COSMIC (genes):COL4A2 COL4A2
CTD Gene:1284 COL4A2
dbSNP Gene:1284 COL4A2
ENSEMBL:ENSG00000134871 COL4A2
ENSEMBL_homo_sapiens_GENE:ENSG00000134871.19 COL4A2
HGNC:2203 COL4A2
KEGG Gene (Homo sapiens):1284 COL4A2
Monarch:1284 COL4A2
NCBI Gene:1284 COL4A2
OMIM:120090 COL4A2
UCSC:P08572 COL4A2
Reference Transcript
RefSeq:NM_001846.3 COL4A2
Other Identifiers
11715451_a_at
11715452_s_at
11715453_a_at
1284
16776431
211964_PM_at
211964_at
211966_PM_at
211966_at
3501224
3501225
3501226
3501227
3501247
3501263
3501264
3501266
3501268
3501269
3501270
3501273
3501275
3501278
3501279
3501280
3501282
3501286
3501289
3501293
3501295
3501300
3501301
3501305
3501306
3501308
3501310
3501311
3501312
3501316
3501317
3501318
3501327
3501328
3501329
3501331
3501332
3501333
3501334
3501335
3501337
3501339
3501340
3501343
3501346
3501348
3501349
3501350
3501351
3501352
3501355
3501356
3501359
3501360
3501363
3501364
3501365
3501366
3501367
3501368
3501369
36659_at
70626_at
7970033
A_14_P118100
A_23_P205031
GE59670
GE86395
GO:0001525
GO:0005198
GO:0005201
GO:0005515
GO:0005576
GO:0005581
GO:0005587
GO:0005604
GO:0005615
GO:0005783
GO:0005788
GO:0006351
GO:0014823
GO:0016525
GO:0023052
GO:0030020
GO:0030154
GO:0030198
GO:0030312
GO:0031012
GO:0035987
GO:0038063
GO:0043226
GO:0048856
GO:0060090
GO:0062023
GO:0070062
GO:0071560
HMNXSV003050909
Hs.75617.0.A1_3p_at
Hs.75617.0.A2_3p_at
ILMN_1724994
M24766_s_at
PH_hs_0024713
TC13000392.hg
TC13001293.hg
X05610_at
Participates
as a member of
Canstatin [extracellular region] (Homo sapiens)
Other forms of this molecule
3x4Hyp-3Hyp-GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
3x4Hyp-GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
COL4A2(26-1712) [endoplasmic reticulum lumen]
3x4Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen]
3x4Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
3,4-Hyp 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region]
4-Hyp 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region]
5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region]
GalHyl-COL4A2(26-?) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL4A2(26-?) [extracellular region]
3x4Hyp-GalHyl-COL4A2(?-1712) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL4A2(26-?) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL4A2(26-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL4A2(?-1712) [extracellular region]
5Hyl-COL4A2(26-?) [extracellular region]
5Hyl-COL4A2(?-1712) [extracellular region]
GlcGalHyl-COL4A2(26-?) [extracellular region]
GlcGalHyl-COL4A2(?-1712) [extracellular region]
3,4-Hyp 5-Gal-Hyl collagen alpha-2(IV) chain C-term fragment [extracellular region]
3x4Hyp-5Hyl-COL4A2(?-1712) [extracellular region]
COL4A2(26-?) [extracellular region]
3x4Hyp-3Hyp-COL4A2(?-1712) [extracellular region]
GalHyl-COL4A2(?-1712) [extracellular region]
3x4Hyp-3Hyp-COL4A2(26-?) [extracellular region]
3x4Hyp-COL4A2(?-1712) [extracellular region]
3x4Hyp-GlcGalHyl-COL4A2(26-?) [extracellular region]
3x4Hyp-GlcGalHyl-COL4A2(?-1712) [extracellular region]
3x4Hyp-5Hyl-COL4A2(26-?) [extracellular region]
3x4Hyp-GalHyl-COL4A2(26-?) [extracellular region]
3x4Hyp-COL4A2(26-?) [extracellular region]
COL4A2(?-1712) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL4A2(?-1712) [extracellular region]
3x4Hyp-COL4A2(1486-1712) [extracellular region]
5Hyl-COL4A2(1486-1712) [extracellular region]
3x4Hyp-5Hyl-COL4A2(1486-1712) [extracellular region]
COL4A2(1486-1712) [extracellular region]
GalHyl-COL4A2(1486-1712) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL4A2(1486-1712) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL4A2(1486-1712) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL4A2(1486-1712) [extracellular region]
COL4A2(184-1712) [extracellular region]
3x4Hyp-COL4A2(184-1712) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL4A2(184-1712) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL4A2(184-1712) [extracellular region]
3x4Hyp-GalHyl-COL4A2(184-1712) [extracellular region]
5Hyl-COL4A2(184-1712) [extracellular region]
GlcGalHyl-COL4A2(184-1712) [extracellular region]
3x4Hyp-5Hyl-COL4A2(184-1712) [extracellular region]
3x4Hyp-GlcGalHyl-COL4A2(184-1712) [extracellular region]
GalHyl-COL4A2(184-1712) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL4A2(184-1712) [extracellular region]
3x4Hyp-3Hyp-COL4A2(184-1712) [extracellular region]
GlcGalHyl-COL4A2(1486-1712) [extracellular region]
3x4Hyp-GalHyl-COL4A2(1486-1712) [extracellular region]
3x4Hyp-GlcGalHyl-COL4A2(1486-1712) [extracellular region]
Inferred To
3x4Hyp-3Hyp-COL4A2(1486-1712) [extracellular region]
(Bos taurus)
3x4Hyp-3Hyp-COL4A2(1486-1712) [extracellular region]
(Drosophila melanogaster)
3x4Hyp-3Hyp-COL4A2(1486-1712) [extracellular region]
(Gallus gallus)
col4a2 [extracellular region]
(Xenopus tropicalis)
Col4a2 [extracellular region]
(Mus musculus)
Col4a2 [extracellular region]
(Rattus norvegicus)
Col4a1 [extracellular region]
(Drosophila melanogaster)
Homologues of 3x4Hyp-3Hyp-COL4A2(1486-1712) [extracellular region]
(Caenorhabditis elegans)
Homologues of 3x4Hyp-3Hyp-COL4A2(1486-1712) [extracellular region]
(Drosophila melanogaster)
emb-9 [extracellular region]
(Caenorhabditis elegans)
COL4A2 [extracellular region]
(Canis familiaris)
COL4A2 [extracellular region]
(Sus scrofa)
let-2 [extracellular region]
(Caenorhabditis elegans)
Modified Residues
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,3S)-3-hydroxyproline at unknown position
PsiMod Name
(2S,3S)-3-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.
Cross References
RefSeq
NP_001837.2
OpenTargets
ENSG00000134871
HPA
ENSG00000134871-COL4A2
GeneCards
P08572
Ensembl
ENSP00000353654
,
ENSG00000134871
,
ENST00000360467
PRO
P08572
Pharos - Targets
P08572
Orphanet
20792
PDB
6MPX
,
5NB2
,
1LI1
,
5NAX
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14780 MMP9
8
MMP9 [ficolin-1-rich granule lumen]
(R-HSA-6800973)
MMP9 [tertiary granule lumen]
(R-HSA-6800181)
MMP9(60-106) [extracellular region]
(R-HSA-1604699)
MMP9(60-707) [extracellular region]
(R-HSA-1604726)
MMP9(20-59) [extracellular region]
(R-HSA-1604685)
MMP9(20-106) [extracellular region]
(R-HSA-1604713)
MMP9(20-707) [extracellular region]
(R-HSA-1604376)
MMP9(107-707) [extracellular region]
(R-HSA-668812)
0.527
2
UniProt:P08253 MMP2
5
MMP2(67-109) [extracellular region]
(R-HSA-1604371)
MMP2(67-660) [extracellular region]
(R-HSA-1604345)
MMP2(30-66) [extracellular region]
(R-HSA-1604347)
MMP2(30-660) [extracellular region]
(R-HSA-1604364)
MMP2(110-660) [extracellular region]
(R-HSA-381456)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
