Sialidases 1-4 (NEU1-4, neuraminidases, receptor-destroying enzymes, RDEs) hydrolyze sialic acids (N-acetylneuraminic acid, Neu5Ac) to produce asialo compounds, a step in the degradation process of glycoproteins and gangliosides and are expressed in a variety of cellular locations. NEU2 (cytosolic sialidase) hydrolyzes Neu5Ac from glycoconjugates with alpha2,3-, alpha2,6- or alpha2,8-linked terminal sialated residues in the cytosol (Monti et al. 1999, Chavas et al. 2005).
Tettamanti, G, Wakatsuki, S, Kato, R, Venerando, B, Monti, E, Fusi, P, Chavas, LM, Tringali, C
Borsani, G, Preti, A, Ballabio, A, Rossi, E, Monti, E
exo-alpha-sialidase activity of NEU2 [cytosol]
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