NEU2 hydrolyzes Neu5Ac from glycoconjugates

Stable Identifier
R-HSA-4085029
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sialidases 1-4 (NEU1-4, neuraminidases, receptor-destroying enzymes, RDEs) hydrolyze sialic acids (N-acetylneuraminic acid, Neu5Ac) to produce asialo compounds, a step in the degradation process of glycoproteins and gangliosides and are expressed in a variety of cellular locations. NEU2 (cytosolic sialidase) hydrolyzes Neu5Ac from glycoconjugates with alpha2,3-, alpha2,6- or alpha2,8-linked terminal sialated residues in the cytosol (Monti et al. 1999, Chavas et al. 2005).

Literature References
PubMed ID Title Journal Year
10191093 Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases

Monti, E, Preti, A, Rossi, E, Ballabio, A, Borsani, G

Genomics 1999
15501818 Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition

Chavas, LM, Tringali, C, Fusi, P, Venerando, B, Tettamanti, G, Kato, R, Monti, E, Wakatsuki, S

J. Biol. Chem. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
exo-alpha-sialidase activity of NEU2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created