ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)

Stable Identifier
Reaction [transition]
Homo sapiens
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The alpha-2,3-sialyltransferases 1-6 (ST3GAL1-6) are able to transfer a sialic acid (Neu5Ac) moiety to the terminal galactosyl (Gal-R) residue of O-glycosylated proteins and some gangliosides. Neu5Ac is added to Gal-R via an alpha-2,3 linkage (Shang et al. 1999, Kim et al. 1996, Kitagawa & Paulson 1993, Basu et al. 1993, Ishii et al. 1998, Okajima et al. 1999). Once sialylated, glycoconjugates translocate to the plasma membrane by an unknown mechanism. For simplicity, Gal is shown in a generic form where R represents other sugars O-linked to proteins which can result in a large variability in glycoconjugate structures.
Literature References
PubMed ID Title Journal Year
8920913 Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II)

Lee, YC, Kim, CH, Kim, YJ, Tsuji, S, Kim, KS, Choe, IS, Kim, SH, Ko, JH

Biochem Biophys Res Commun 1996
8611500 Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line

Basu, S, Basu, M, Li, Z, Basu, SS

Biochemistry 1996
9822625 Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase

Matsuda, K, Saito, M, Inokuchi, J, Ishii, A, Sakoe, K, Sanai, Y, Ohta, M, Ishiyama, K, Watanabe, Y, Nakamura, M

J. Biol. Chem. 1998
10206952 Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids

Kiso, M, Fukumoto, S, Miyazaki, H, Urano, T, Furukawa, K, Furukawa, K, Ishida, H, Okajima, T

J Biol Chem 1999
8333853 Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase

Kitagawa, H, Paulson, JC

Biochem Biophys Res Commun 1993
10504389 Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver

Ding, H, Qiu, R, Liu, J, Jin, C, Yang, S, Shang, J, Zhou, R, Zhang, S, Wang, J

Eur J Biochem 1999
Catalyst Activity

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL1-6 [Golgi membrane]

Orthologous Events
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