CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac

Stable Identifier
R-HSA-4084982
Type
Reaction
Species
Homo sapiens
Compartment
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Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase1 (CMAS) transfers cytidine 5-monophosphate from a CTP donor to N-acetylneuraminate (Neu5Ac) to form CMP-Neu5Ac. CMAS is ubiquitously expressed and localizes to the nucleus in mammalian cells. The active form of the enzyme is a homotetramer (a dimer of dimers) (Lawrence et al. 2001, Huizing 2005). CMP-Neu5Ac is the donor substrate for sialyltransferases.

Literature References
PubMed ID Title Journal Year
  Disease mechanisms associated with mutations of the GNE gene

Huizing, M

   
  Disease mechanisms associated with mutations of the GNE gene

Huizing, M

  2005
11602804 Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells

Nguyen, N, Coleman, TA, Huddleston, KA, Lee, YC, Lawrence, SM, Betenbaugh, MJ, Vann, WF, Tomiya, N

Glycoconj. J. 2001
Participants
Participates
Catalyst Activity

N-acylneuraminate cytidylyltransferase activity of CMAS tetramer [nucleoplasm]

Orthologous Events
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