CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac

Stable Identifier
R-HSA-4084982
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase1 (CMAS) transfers cytidine 5-monophosphate from a CTP donor to N-acetylneuraminate (Neu5Ac) to form CMP-Neu5Ac. CMAS is ubiquitously expressed and localizes to the nucleus in mammalian cells. The active form of the enzyme is a homotetramer (a dimer of dimers) (Lawrence et al. 2001, Huizing 2005). CMP-Neu5Ac is the donor substrate for sialyltransferases.

Literature References
PubMed ID Title Journal Year
  Disease mechanisms associated with mutations of the GNE gene

Huizing, M

  2005
  Disease mechanisms associated with mutations of the GNE gene

Huizing, M

   
11602804 Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells

Lawrence, SM, Huddleston, KA, Tomiya, N, Nguyen, N, Lee, YC, Vann, WF, Coleman, TA, Betenbaugh, MJ

Glycoconj. J. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
N-acylneuraminate cytidylyltransferase activity of CMAS tetramer [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created