Reactome | CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac

CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac

Stable Identifier

R-HSA-4084982

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Homo sapiens)

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CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac

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Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase1 (CMAS) transfers cytidine 5-monophosphate from a CTP donor to N-acetylneuraminate (Neu5Ac) to form CMP-Neu5Ac. CMAS is ubiquitously expressed and localizes to the nucleus in mammalian cells. The active form of the enzyme is a homotetramer (a dimer of dimers) (Lawrence et al. 2001, Huizing 2005). CMP-Neu5Ac is the donor substrate for sialyltransferases.

Literature References

PubMed ID	Title	Journal	Year
	Disease mechanisms associated with mutations of the GNE gene Huizing, M
	Disease mechanisms associated with mutations of the GNE gene Huizing, M		2005
11602804	Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells Nguyen, N, Coleman, TA, Huddleston, KA, Lee, YC, Lawrence, SM, Betenbaugh, MJ, Vann, WF, Tomiya, N	Glycoconj. J.	2001