Active Rac1 interacts with Plexin-B1:Sema4D

Stable Identifier
R-HSA-400682
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Active Rac1 interacts with Plexin-B1:Sema4A
ReviewStatus
5/5
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Active Rac1 interacts with Plexin-B1:Sema4D
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The cytoplasmic tails of plexins have two domains, C1 and C2, which are highly conserved and act as GAP for small GTPases like Rac1. Active Rac1 binds directly to a binding domain of Plexin-B1 in the linker region between C1 and C2. The functional consequence of the plexin-B1/Rac interaction is not understood but this binding might sequester Rac1 away from p21-activated kinase (PAK). Plexin-B1 can compete with PAK for binding to active Rac and this competition results in the ability of plexin-B1 to inhibit Rac-induced PAK activation.
Literature References
PubMed ID Title Journal Year
11937491 The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

Guan, KL, Vikis, HG, Li, W

Genes Dev 2002
11035813 The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner

Guan, KL, Vikis, HG, He, Z, Li, W

Proc Natl Acad Sci U S A 2000
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Orthologous Events
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Active Rac1 interacts with Plexin-B1:Sema4D (Mus musculus)
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Active Rac1 interacts with Plexin-B1:Sema4D (Sus scrofa)
Active Rac1 interacts with Plexin-B1:Sema4D (Xenopus tropicalis)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kikutani, H  (2009-09-02)
Kumanogoh, A  (2009-09-02)
Created
Garapati, P V  (2009-03-24)
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