Active Rac1 interacts with Plexin-B1:Sema4D

Stable Identifier
R-HSA-400682
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Active Rac1 interacts with Plexin-B1:Sema4A
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The cytoplasmic tails of plexins have two domains, C1 and C2, which are highly conserved and act as GAP for small GTPases like Rac1. Active Rac1 binds directly to a binding domain of Plexin-B1 in the linker region between C1 and C2. The functional consequence of the plexin-B1/Rac interaction is not understood but this binding might sequester Rac1 away from p21-activated kinase (PAK). Plexin-B1 can compete with PAK for binding to active Rac and this competition results in the ability of plexin-B1 to inhibit Rac-induced PAK activation.

Literature References
PubMed ID Title Journal Year
11035813 The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner

Vikis, HG, Li, W, He, Z, Guan, KL

Proc Natl Acad Sci U S A 2000
11937491 The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

Vikis, HG, Li, W, Guan, KL

Genes Dev 2002
Participants
Participant Of
Orthologous Events
Authored
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Created