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FFAR4 [plasma membrane]
Stable Identifier
R-HSA-400502
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GPR120, G-protein coupled receptor 120 , GP120_HUMAN, G-protein coupled receptor PGR4, G-protein coupled receptor GT01, G-protein coupled receptor 129
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)
FFAR4:FFAR4 ligands [plasma membrane] (Homo sapiens)
FFAR4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR4:FFAR4 ligands [plasma membrane] (Homo sapiens)
FFAR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR4:FFAR4 ligands [plasma membrane] (Homo sapiens)
FFAR4 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR4:FFAR4 ligands [plasma membrane] (Homo sapiens)
FFAR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR4:FFAR4 ligands [plasma membrane] (Homo sapiens)
FFAR4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR4:FFAR4 ligands [plasma membrane] (Homo sapiens)
FFAR4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Free fatty acid receptors (Homo sapiens)
GPR120 is a receptor for unsaturated long-chain free fatty acids (Homo sapiens)
FFAR4 [plasma membrane] (Homo sapiens)
FFAR4:FFAR4 ligands [plasma membrane] (Homo sapiens)
FFAR4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5NUL3 FFAR4
Gene Names
FFAR4, GPR120, GPR129, O3FAR1, PGR4
Chain
chain:1-361
Reference Genes
BioGPS Gene:338557 FFAR4
COSMIC (genes):FFAR4 FFAR4
CTD Gene:338557 FFAR4
dbSNP Gene:338557 FFAR4
ENSEMBL:ENSG00000186188 FFAR4
HGNC:19061 FFAR4
KEGG:hsa:338557 FFAR4
Monarch:338557 FFAR4
NCBI Gene:338557 FFAR4
OMIM:609044 FFAR4
UCSC:Q5NUL3 FFAR4
Reference Transcript
RefSeq:NM_001195755.1 FFAR4
RefSeq:NM_181745.3 FFAR4
Other Identifiers
11735811_a_at
11735812_x_at
11761915_at
16707567
240856_PM_at
240856_at
3258626
3258627
3258630
3258632
3258637
3258638
3258639
3258649
3258651
3258653
3258655
3258657
3258659
338557
55966_at
7929344
A_14_P116357
A_24_P129588
GE506702
GO:0001818
GO:0004930
GO:0005504
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005886
GO:0005929
GO:0006954
GO:0007165
GO:0007186
GO:0007189
GO:0007200
GO:0007204
GO:0008289
GO:0008527
GO:0010008
GO:0010827
GO:0016020
GO:0030139
GO:0030154
GO:0031410
GO:0032691
GO:0032870
GO:0036321
GO:0042277
GO:0042995
GO:0043066
GO:0043226
GO:0045444
GO:0045669
GO:0046879
GO:0050728
GO:0050872
GO:0050873
GO:0050912
GO:0060089
GO:0060170
GO:0070094
GO:0070374
GO:0090275
GO:0090336
GO:0120162
GO:1990763
HMNXSV003053802
Hs.71999.0.A1_3p_at
Hs.76461.1.A1_3p_a_at
ILMN_1755942
PH_hs_0026264
TC10000665.hg
TC10002222.hg
Participates
as an input of
GPR120 is a receptor for unsaturated long-chain free fatty acids (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
FFAR4:FFAR4 ligands [plasma membrane] (Homo sapiens)
Inferred To
TrissinR [plasma membrane]
(Drosophila melanogaster)
FFAR4 [plasma membrane]
(Bos taurus)
FFAR4 [plasma membrane]
(Canis familiaris)
FFAR4 [plasma membrane]
(Gallus gallus)
FFAR4 [plasma membrane]
(Sus scrofa)
Ffar4 [plasma membrane]
(Rattus norvegicus)
pcdr-1 [plasma membrane]
(Caenorhabditis elegans)
Gpr120 [plasma membrane]
(Mus musculus)
Cross References
RefSeq
NP_859529.2
,
NP_001182684.1
Guide to Pharmacology - Targets
127
ENSEMBL
ENSP00000360536
,
ENSP00000360538
,
ENST00000371483
,
ENST00000371481
,
ENSG00000186188
OpenTargets
ENSG00000186188
ZINC - Substances
FFAR4_HUMAN
ZINC - Biogenic
FFAR4_HUMAN
ZINC target
Q5NUL3
PRO
Q5NUL3
GlyGen
Q5NUL3
PDB
8ID4
,
8H4I
,
8IYS
,
8G59
,
8ID8
,
8ID9
,
8ID3
,
8H4L
,
8ID6
,
8H4K
,
8T3O
,
8T3Q
ZINC - Metabolites
FFAR4_HUMAN
GeneCards
FFAR4
HPA
ENSG00000186188-FFAR4
Pharos - Targets
Q5NUL3
ZINC - Predictions - Purchasable
FFAR4_HUMAN
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