Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells

Stable Identifier
R-HSA-400500
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol, endoplasmic reticulum lumen
ReviewStatus
5/5
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Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells
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The transcription factors PDX-1 and PAX6 binds the promoter of the human GIP gene between 145 and 184 nucleotides upstream of the start of transcription and enhance transcription of GIP. In mouse Pdx-1 also increases the number of GIP-producing K cells. Consensus binding sites for other transcription factors such as AP-1, AP-2, and Sp1 have been identified in the promoter of the GIP gene but their role is unknown. The human GIP promoter is responsive to cAMP by an unknown mechanism.
Literature References
PubMed ID Title Journal Year
18593849 Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells

Fujita, Y, Chui, JW, King, DS, Zhang, T, Seufert, J, Pownall, S, Cheung, AT, Kieffer, TJ

Am J Physiol Endocrinol Metab 2008
8428636 Two 3',5'-cyclic-adenosine monophosphate response elements in the promoter region of the human gastric inhibitory polypeptide gene

Someya, Y, Inagaki, N, Maekawa, T, Seino, Y, Ishii, S

FEBS Lett 1993
16219666 Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP

Theodorakis, MJ, Carlson, O, Michopoulos, S, Doyle, ME, Juhaszova, M, Petraki, K, Egan, JM

Am J Physiol Endocrinol Metab 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
PAX6 [nucleoplasm] (Homo sapiens)
Regulator
GATA4 [nucleoplasm] (Homo sapiens)
Regulator
ISL1 [nucleoplasm] (Homo sapiens)
Authored
May, B  (2009-05-19)
Reviewed
Bloom, SR  (2010-06-25)
Created
May, B  (2009-03-24)
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