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BMAL1:CLOCK,NPAS2

Stable Identifier
R-HSA-400360
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
ARNTL:CLOCK,NPAS2
Locations in the PathwayBrowser
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Summation

BMAL1 (ARNTL) contains both a nuclear localization signal and a nuclear export signal. The shuttling of BMAL1 between the nucleus and cytoplasm is important for transactivation by BMAL1:CLOCK/NPAS2 and degradation of BMAL1:CLOCK/NPAS2. BMAL1 initially forms a heterodimer with CLOCK or NPAS2 in the cytosol. The heterodimer is then phosphorylated and translocated into the nucleus.

Participants
components
Participant Of
input
hasComponent
output
Inferred From
Bmal1:Clock,Npas2 [cytosol] (Mus musculus)