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BMAL1:CLOCK,NPAS2 [cytosol]
Stable Identifier
R-HSA-400360
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
ARNTL:CLOCK,NPAS2
Locations in the PathwayBrowser
Expand all
Circadian Clock (Homo sapiens)
BMAL1 binds CLOCK,NPAS2 forming BMAL1:CLOCK,NPAS2 heterodimer (Homo sapiens)
BMAL1:CLOCK,NPAS2 [cytosol] (Homo sapiens)
BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus (Homo sapiens)
BMAL1:CLOCK,NPAS2 [cytosol] (Homo sapiens)
CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2 (Homo sapiens)
BMAL1:CLOCK,NPAS2 [cytosol] (Homo sapiens)
BMAL1:CLOCK,NPAS2:CRY [cytosol] (Homo sapiens)
BMAL1:CLOCK,NPAS2 [cytosol] (Homo sapiens)
General
BMAL1 (ARNTL) contains both a nuclear localization signal and a nuclear export signal. The shuttling of BMAL1 between the nucleus and cytoplasm is important for transactivation by BMAL1:CLOCK/NPAS2 and degradation of BMAL1:CLOCK/NPAS2. BMAL1 initially forms a heterodimer with CLOCK or NPAS2 in the cytosol. The heterodimer is then phosphorylated and translocated into the nucleus.
Participants
components
ARNTL [cytosol]
(Homo sapiens)
CLOCK,NPAS2 [cytosol]
(Homo sapiens)
Participates
as a component of
BMAL1:CLOCK,NPAS2:CRY [cytosol] (Homo sapiens)
as an input of
CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2 (Homo sapiens)
BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus (Homo sapiens)
as an output of
BMAL1 binds CLOCK,NPAS2 forming BMAL1:CLOCK,NPAS2 heterodimer (Homo sapiens)
Inferred From
Bmal1:Clock,Npas2 [cytosol]
(Mus musculus)
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