BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins

Stable Identifier
R-HSA-400267
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Polyubiquitination of PER proteins is directed by the Beta-TrCP1 component of SCF E3 ubiquitin ligase. The polyubiquitinated PER proteins are recognized and degraded by the 26S proteasome. Degradation of PER proteins occurs during the night and is necessary to allow new transcription of BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) targets in the morning during the circadian cycle.

Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of BTRC:CUL1:SKP1 [cytosol]

Inferred From
Authored
Reviewed
Created
Cite Us!