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Beta-TrCP1 binds phosphorylated PER proteins
Stable Identifier
R-HSA-400219
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Circadian Clock (Homo sapiens)
Beta-TrCP1 binds phosphorylated PER proteins (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Beta-TrCP1 is an F-box type component of a particular SKP/CUL/F-Box (SCF) E3 ubiquitin ligase. Beta-TrCP1 interacts specifically with phosphorylated PER proteins and directs their polyubiquitination.
Literature References
PubMed ID
Title
Journal
Year
15917222
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein
Shirogane, T
,
Ang, XL
,
Jin, J
,
Harper, JW
J Biol Chem
2005
Participants
Input
BTRC [cytosol]
(Homo sapiens)
p-PER1,p-PER2 [cytosol]
(Homo sapiens)
Output
Beta-TrCP1:PER [cytosol]
(Homo sapiens)
Participates
as an event of
Circadian Clock (Homo sapiens)
Inferred From
Beta-TrCP (Btrc) binds phosphorylated Per (Mus musculus)
Authored
May, B (2009-05-18)
Reviewed
Delaunay, F (2010-06-23)
Hirota, T (2010-06-23)
Kay, SA (2010-06-23)
Albrecht, U (2010-06-23)
D'Eustachio, P (2009-05-27)
Created
May, B (2009-03-24)
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