Adenylyl cyclases V and VI are the particular adenylyl cyclases present in beta cells of the human pancreas. The G-protein beta-gamma complex interacts with adenylyl cyclases via protein-protein interactions with the C1 and C2 cytoplasmic loops of adenylyl cyclase. The interaction may produce either stimulation or inhibition of the adenylyl cyclase depending on the particular adenylyl cyclase. In the case of adenylyl cyclases V and VI the interaction inhibits cyclase activity.
Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I
Sharp, GW
Pfeuffer, T, Vogel, Z, Bayewitch, ML, Nevo, I, Avidor-Reiss, T, Simonds, WF, Levy, R
Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S
Rouot, B, Paris, H, Remaury, A, Daviaud, D, Larrouy, D
Wittpoth, C, Scholich, K, Yigzaw, Y, Patel, TB, Stringfield, TM
Habener, JF, Castonguay, MA, Leech, CA
Ahren, B, Winzell, MS
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