G-beta:G-gamma inhibits Adenylate cyclase

Stable Identifier
Reaction [binding]
Homo sapiens
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Adenylyl cyclases V and VI are the particular adenylyl cyclases present in beta cells of the human pancreas. The G-protein beta-gamma complex interacts with adenylyl cyclases via protein-protein interactions with the C1 and C2 cytoplasmic loops of adenylyl cyclase. The interaction may produce either stimulation or inhibition of the adenylyl cyclase depending on the particular adenylyl cyclase. In the case of adenylyl cyclases V and VI the interaction inhibits cyclase activity.

Literature References
PubMed ID Title Journal Year
7641683 Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I

EMBO J 1995
8997178 Mechanisms of inhibition of insulin release

Sharp, GW

Am J Physiol 1996
9707174 Inhibition of adenylyl cyclase isoforms V and VI by various Gbetagamma subunits

Pfeuffer, T, Vogel, Z, Bayewitch, ML, Nevo, I, Avidor-Reiss, T, Simonds, WF, Levy, R

FASEB J 1998
14514350 Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice

Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S

Eur J Endocrinol 2003
8099279 Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells

Rouot, B, Paris, H, Remaury, A, Daviaud, D, Larrouy, D

Biochem J 1993
10449730 Regions on adenylyl cyclase that are necessary for inhibition of activity by beta gamma and G(ialpha) subunits of heterotrimeric G proteins

Wittpoth, C, Scholich, K, Yigzaw, Y, Patel, TB, Stringfield, TM

Proc Natl Acad Sci U S A 1999
9920805 Expression of adenylyl cyclase subtypes in pancreatic beta-cells

Habener, JF, Castonguay, MA, Leech, CA

Biochem Biophys Res Commun 1999
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
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