Reactome | G-beta:G-gamma inhibits Adenylate cyclase

G-beta:G-gamma inhibits Adenylate cyclase

Stable Identifier

R-HSA-400097

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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G-beta:G-gamma inhibits Adenylate cyclase

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Adenylyl cyclases V and VI are the particular adenylyl cyclases present in beta cells of the human pancreas. The G-protein beta-gamma complex interacts with adenylyl cyclases via protein-protein interactions with the C1 and C2 cytoplasmic loops of adenylyl cyclase. The interaction may produce either stimulation or inhibition of the adenylyl cyclase depending on the particular adenylyl cyclase. In the case of adenylyl cyclases V and VI the interaction inhibits cyclase activity.

Literature References

PubMed ID	Title	Journal	Year
7641683	Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits Lang, J, Nishimoto, I, Okamoto, T, Regazzi, R, Kiraly, C, Weller, U, Wollheim, CB	EMBO J	1995
8997178	Mechanisms of inhibition of insulin release Sharp, GW	Am J Physiol	1996
9707174	Inhibition of adenylyl cyclase isoforms V and VI by various Gbetagamma subunits Bayewitch, ML, Avidor-Reiss, T, Levy, R, Pfeuffer, T, Nevo, I, Simonds, WF, Vogel, Z	FASEB J	1998
14514350	Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice Peterhoff, M, Sieg, A, Brede, M, Chao, CM, Hein, L, Ullrich, S	Eur J Endocrinol	2003
8099279	Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells Remaury, A, Larrouy, D, Daviaud, D, Rouot, B, Paris, H	Biochem J	1993
10449730	Regions on adenylyl cyclase that are necessary for inhibition of activity by beta gamma and G(ialpha) subunits of heterotrimeric G proteins Wittpoth, C, Scholich, K, Yigzaw, Y, Stringfield, TM, Patel, TB	Proc Natl Acad Sci U S A	1999
9920805	Expression of adenylyl cyclase subtypes in pancreatic beta-cells Leech, CA, Castonguay, MA, Habener, JF	Biochem Biophys Res Commun	1999
17900700	G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes Winzell, MS, Ahren, B	Pharmacol Ther	2007