Low conductance potassium channels in pancreatic beta cells open in response to epinephrine

Stable Identifier
R-HSA-400063
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Low conductance potassium channels in pancreatic beta cells open in response to epinephrine
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ATP-sensitive Potassium channels open and allow an inward rectifying current of potassium ions to flow, reestablishing the resting potential of the cell.
Literature References
PubMed ID Title Journal Year
7641683 Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

Lang, J, Nishimoto, I, Okamoto, T, Regazzi, R, Kiraly, C, Weller, U, Wollheim, CB

EMBO J 1995
8997178 Mechanisms of inhibition of insulin release

Sharp, GW

Am J Physiol 1996
14514350 Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice

Peterhoff, M, Sieg, A, Brede, M, Chao, CM, Hein, L, Ullrich, S

Eur J Endocrinol 2003
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Winzell, MS, Ahren, B

Pharmacol Ther 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

potassium channel activator activity of G-alpha(i,o):GTP [plasma membrane]

Physical Entity
G-alpha(i,o):GTP [plasma membrane] (Homo sapiens)
Activity
potassium channel activator activity (GO:0099104)
Inferred From
Opening of Low Conductance Potassium Channels (Mus musculus)
Authored
May, B  (2009-05-27)
Reviewed
D'Eustachio, P  (2009-06-02)
Hill, DP  (2025-06-02)
Created
May, B  (2009-03-24)
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