Gi,Go Heterotrimeric G-protein complex dissociates

Stable Identifier
Reaction [dissociation]
Homo sapiens
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Exchange of GDP for GTP by the alpha subunit of the heterotrimeric G-protein complex causes the complex to dissociate into the G alpha:GTP complex and the beta-gamma complex. Both complexes have effector functions.

Literature References
PubMed ID Title Journal Year
7641683 Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I

EMBO J 1995
8997178 Mechanisms of inhibition of insulin release

Sharp, GW

Am J Physiol 1996
14514350 Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice

Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S

Eur J Endocrinol 2003
17095603 Some G protein heterotrimers physically dissociate in living cells

Lambert, NA, Digby, GJ, Sethi, PR, Lober, RM

Proc Natl Acad Sci U S A 2006
19258039 The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

Lambert, NA, Digby, GJ, Hollins, B, Kuravi, S

Cell Signal 2009
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
16373322 GPCR-induced dissociation of G-protein subunits in early stage signal transduction

Bucco, O, Aloia, AL, McMurchie, EJ, Leifert, WR

Mol Membr Biol 2005
18162464 Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel

Straub, SG, Fang, Q, Sharp, GW, Zhao, Y

J Biol Chem 2008
Orthologous Events
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