Reactome | Gi,Go Heterotrimeric G-protein complex dissociates

Gi,Go Heterotrimeric G-protein complex dissociates

Stable Identifier

R-HSA-400037

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Gi,Go Heterotrimeric G-protein complex dissociates

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Exchange of GDP for GTP by the alpha subunit of the heterotrimeric G-protein complex causes the complex to dissociate into the G alpha:GTP complex and the beta-gamma complex. Both complexes have effector functions.

Literature References

PubMed ID	Title	Journal	Year
7641683	Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I	EMBO J	1995
8997178	Mechanisms of inhibition of insulin release Sharp, GW	Am J Physiol	1996
14514350	Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S	Eur J Endocrinol	2003
17095603	Some G protein heterotrimers physically dissociate in living cells Lambert, NA, Digby, GJ, Sethi, PR, Lober, RM	Proc Natl Acad Sci U S A	2006
19258039	The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers Lambert, NA, Digby, GJ, Hollins, B, Kuravi, S	Cell Signal	2009
17900700	G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes Ahren, B, Winzell, MS	Pharmacol Ther	2007
16373322	GPCR-induced dissociation of G-protein subunits in early stage signal transduction Bucco, O, Aloia, AL, McMurchie, EJ, Leifert, WR	Mol Membr Biol	2005
18162464	Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel Straub, SG, Fang, Q, Sharp, GW, Zhao, Y	J Biol Chem	2008