Reactome | Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma

Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma

Stable Identifier

R-HSA-400027

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma

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In the non-activated state heterotrimeric G proteins exist at membranes as heterotrimeric complexes of alpha, beta, and gamma subunits, with the alpha subunit bound to GDP. Upon activation by a receptor coupled to the heterotrimer, exchange of GDP for GTP by the Gq alpha subunit causes the alpha subunit to lose affinity for the beta and gamma subunits. The alpha subunit with bound GTP then dissociates from the beta and gamma subunits.

Literature References

PubMed ID	Title	Journal	Year
16339447	Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex Shankaranarayanan, A, Tesmer, JJ, Kozasa, T, Tesmer, VM, Kawano, T	Science	2005
16242307	G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type Azpiazu, I, Kalyanaraman, V, Akgoz, M, Gautam, N	Cell Signal	2006
17095603	Some G protein heterotrimers physically dissociate in living cells Lambert, NA, Digby, GJ, Sethi, PR, Lober, RM	Proc Natl Acad Sci U S A	2006
17962409	Galpha Gbetagamma dissociation may be due to retraction of a buried lysine and disruption of an aromatic cluster by a GTP-sensing Arg Trp pair Neuwald, AF	Protein Sci	2007
15448129	Receptor-mediated reversible translocation of the G protein betagamma complex from the plasma membrane to the Golgi complex Kalyanaraman, V, Akgoz, M, Gautam, N	J Biol Chem	2004
19212142	Structural determinants involved in the formation and activation of G protein betagamma dimers McIntire, WE	Neurosignals	2009

Participants

Input

G-alpha(q)11,14,15,Q:G-beta:G-gamma [plasma membrane] (Homo sapiens)

Output

Participates

as an event of

Catalyst Activity

G protein activity of G-alpha(q)11,14,15,Q:G-beta:G-gamma [plasma membrane]

Physical Entity

G-alpha(q)11,14,15,Q:G-beta:G-gamma [plasma membrane] (Homo sapiens)

Activity

G protein activity (GO:0003925)

Authored

May, B (2009-05-28)

Reviewed

Gillespie, ME (2009-06-02)

D'Eustachio, P (2024-01-29)

Created

May, B (2009-03-24)