Muscarinic Acetylcholine Receptor M3 activates Gq

Stable Identifier
R-HSA-399995
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The binding of acetylcholine to the Muscarinic Acetylcholine Receptor M3 activates the heterotrimeric G protein, Gq, associated with the M3 receptor. Activation occurs through protein-protein interaction and results in the alpha subunit of Gq exchanging GDP for GTP (i.e releasing GDP and binding GTP). The 3 subunits of the G protein then dissociate into an alpha:GTP complex and a beta:gamma complex.

Literature References
PubMed ID Title Journal Year
8190105 Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11

Offermanns, S, Wieland, T, Homann, D, Sandmann, J, Bombien, E, Spicher, K, Schultz, G, Jakobs, KH

Mol Pharmacol 1994
18383439 Peptide fragment of the m3 muscarinic acetylcholine receptor activates G(q) but not G(i2)

Kubota, M, Wakamatsu, K

J Pept Sci 2008
16753580 A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

Gautam, D, Han, SJ, Hamdan, FF, Jeon, J, Li, B, Li, JH, Cui, Y, Mears, D, Lu, H, Deng, C, Heard, T, Wess, J

Cell Metab 2006
17919190 Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis

Gautam, D, Han, SJ, Duttaroy, A, Mears, D, Hamdan, FF, Li, JH, Cui, Y, Jeon, J, Wess, J

Diabetes Obes Metab 2007
16871065 Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein

Nakayama, T, Penheiter, AR, Penheiter, SG, Chini, EN, Thompson, M, Warner, DO, Jones, KA

Anesthesiology 2006
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Winzell, MS, Ahren, B

Pharmacol Ther 2007
12194018 Antisense co-suppression of G(alpha)(q) and G(alpha)(11) demonstrates that both isoforms mediate M(3)-receptor-activated Ca(2+) signalling in intact epithelial cells

Cummins, MM, O'Mullane, LM, Barden, JA, Cook, DI, Poronnik, P

Pflugers Arch 2002
11588141 Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

Gilon, P, Henquin, JC

Endocr Rev 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created