Reactome | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Stable Identifier

R-HSA-399955

Type

Pathway

Species

Homo sapiens

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SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

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Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. Sema3A inhibits cell migration by inhibiting integrin ligand-binding activity.

Literature References

PubMed ID	Title	Journal	Year
18580951	The semaphorins: versatile regulators of tumour progression and tumour angiogenesis Neufeld, G, Kessler, O	Nat Rev Cancer	2008
16286926	FARP2 triggers signals for Sema3A-mediated axonal repulsion Toyofuku, T, Yoshida, J, Sugimoto, T, Zhang, H, Kumanogoh, A, Hori, M, Kikutani, H	Nat Neurosci	2005
18374575	Semaphorin signaling: progress made and promises ahead Zhou, Y, Gunput, RA, Pasterkamp, RJ	Trends Biochem Sci	2008