Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. Sema3A inhibits cell migration by inhibiting integrin ligand-binding activity.
Neufeld, G, Kessler, O
Toyofuku, T, Yoshida, J, Sugimoto, T, Zhang, H, Kumanogoh, A, Hori, M, Kikutani, H
Zhou, Y, Gunput, RA, Pasterkamp, RJ
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