Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. Sema3A inhibits cell migration by inhibiting integrin ligand-binding activity.
Zhang, H, Yoshida, J, Toyofuku, T, Kumanogoh, A, Sugimoto, T, Kikutani, H, Hori, M
Kessler, O, Neufeld, G
Zhou, Y, Pasterkamp, RJ, Gunput, RA
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