Autophosphorylation of PAK

Stable Identifier
R-HSA-399939
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PAK is autophosphorylated at several sites but S-144 flanking the kinase inhibitor region and T-423 (S-141/T-402 in PAK-gamma) within the catalytic domain are the two conserved sites that regulate the catalytic activity.

Literature References
PubMed ID Title Journal Year
10075701 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

Gatti, A, Huang, Z, Tuazon, PT, Traugh, JA

J Biol Chem 1999
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Chong, C, Tan, L, Lim, L, Manser, E

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created