Reactome | Autophosphorylation of PAK

Autophosphorylation of PAK

Stable Identifier

R-HSA-399939

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PAK is autophosphorylated at several sites but S-144 flanking the kinase inhibitor region and T-423 (S-141/T-402 in PAK-gamma) within the catalytic domain are the two conserved sites that regulate the catalytic activity.

Literature References

PubMed ID	Title	Journal	Year
11278486	The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity Chong, C, Tan, L, Lim, L, Manser, E	J Biol Chem	2001
10075701	Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation Gatti, A, Huang, Z, Tuazon, PT, Traugh, JA	J Biol Chem	1999