Autophosphorylation of PAK

Stable Identifier
R-HSA-399939
Type
Reaction
Species
Homo sapiens
Compartment
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PAK is autophosphorylated at several sites but S-144 flanking the kinase inhibitor region and T-423 (S-141/T-402 in PAK-gamma) within the catalytic domain are the two conserved sites that regulate the catalytic activity.

Literature References
PubMed ID Title Journal Year
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Manser, E, Lim, L, Chong, C, Tan, L

J Biol Chem 2001
10075701 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

Huang, Z, Traugh, JA, Tuazon, PT, Gatti, A

J Biol Chem 1999
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane]

Orthologous Events
Authored
Reviewed
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