Activation of Rac1 by FARP2

Stable Identifier
R-HSA-399938
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of Rac1 by FARP2
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Sema3A-mediated dissociation of FARP2 from Plexin-A is followed by activation of Rac1 by the GEF activity of released FARP2.
FARP2 is critical for Sema3A-mediated axonal repulsion through two independent downstream signaling pathways. Sema3A mediated disassociation of FARP2 from Plexin-A is followed by activation of Rac by GEF activity of released FARP2, binding of Rnd1 to plexin-A and down regulation of R-Ras by GAP activity of plexin-A.

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Input
Output
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as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of FARP2 [cytosol]

Physical Entity
FARP2 [cytosol] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Inferred From
Activation of Rac1 by FARP2 (Mus musculus)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kikutani, H  (2009-09-02)
Kumanogoh, A  (2009-09-02)
Created
Garapati, P V  (2009-03-23)
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