Activation of PAK by Rac1

Stable Identifier
R-HSA-399930
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of PAK by Rac1
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Plexin-bound Rac1 binds to and stimulates the kinase activity of PAK. PAK dimers are arranged in head-to-tail fashion, in which the catalytic domain binds the kinase inhibitory (KI) domain and is supported by associated PAK-interacting exchange factor (PIX) dimers. Upon Rac1 binding the kinase undergoes conformational change that allows autophosphorylation. Phosphorylation of serine residues disables the KI-domain-kinase interaction and thereby reduces the affinity of PIX.
Literature References
PubMed ID Title Journal Year
11604131 Plexin signaling via off-track and rho family GTPases

Whitford, KL, Ghosh, A

Neuron 2001
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Orthologous Events
Activation of PAK by Rac1 (Bos taurus)
Activation of PAK by Rac1 (Caenorhabditis elegans)
Activation of PAK by Rac1 (Canis familiaris)
Activation of PAK by Rac1 (Danio rerio)
Activation of PAK by Rac1 (Drosophila melanogaster)
Activation of PAK by Rac1 (Gallus gallus)
Activation of PAK by Rac1 (Mus musculus)
Activation of PAK by Rac1 (Rattus norvegicus)
Activation of PAK by Rac1 (Sus scrofa)
Activation of PAK by Rac1 (Xenopus tropicalis)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kikutani, H  (2009-09-02)
Kumanogoh, A  (2009-09-02)
Created
Garapati, P V  (2009-03-23)
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