Activation of PAK by Rac1

Stable Identifier
R-HSA-399930
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Plexin-bound Rac1 binds to and stimulates the kinase activity of PAK. PAK dimers are arranged in head-to-tail fashion, in which the catalytic domain binds the kinase inhibitory (KI) domain and is supported by associated PAK-interacting exchange factor (PIX) dimers. Upon Rac1 binding the kinase undergoes conformational change that allows autophosphorylation. Phosphorylation of serine residues disables the KI-domain-kinase interaction and thereby reduces the affinity of PIX.

Literature References
PubMed ID Title Journal Year
11604131 Plexin signaling via off-track and rho family GTPases

Whitford, KL, Ghosh, A

Neuron 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created