Reactome | p-S534-DPYSL5 [cytosol]

p-S534-DPYSL5 [cytosol]

Stable Identifier

R-HSA-399793

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

pCRAM (S534) , pCRAM-5

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - CRMPs in Sema3A signaling (Homo sapiens)
        
        Phosphorylation of CRMPs by Cdk5 (Homo sapiens)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Homo sapiens)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Homo sapiens)
        
        p-CRMP tetramers [cytosol] (Homo sapiens)
        
        Cdk5 phosphorylated CRMP1-5 [cytosol] (Homo sapiens)
        
        p-S534-DPYSL5 [cytosol] (Homo sapiens)
        
        Phosphorylation of CRMPs by GSK3beta (Homo sapiens)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Homo sapiens)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Homo sapiens)
        
        p-CRMP tetramers [cytosol] (Homo sapiens)
        
        Cdk5 phosphorylated CRMP1-5 [cytosol] (Homo sapiens)
        
        p-S534-DPYSL5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BPU6 DPYSL5

Gene Names

DPYSL5, CRMP5, ULIP6

Chain

chain:1-564

Reference Genes

BioGPS Gene:56896 DPYSL5

COSMIC (genes):DPYSL5 DPYSL5

CTD Gene:56896 DPYSL5

dbSNP Gene:56896 DPYSL5

ENSEMBL:ENSG00000157851.17 DPYSL5

HGNC:20637 DPYSL5

KEGG Gene (Homo sapiens):56896 DPYSL5

Monarch:56896 DPYSL5

NCBI Gene:56896 DPYSL5

OMIM:608383 DPYSL5

UCSC:Q9BPU6 DPYSL5

Reference Transcript

Other Identifiers

11739423_at

11739424_a_at

11739425_at

16877968

222797_PM_at

222797_at

224100_PM_s_at

224100_s_at

2474021

2474022

2474030

2474041

2474043

2474045

2474046

2474047

2474050

2474052

2474053

2474054

2474055

2474056

2474057

2474058

2474059

2474060

2474061

2474062

56896

8040725

A_14_P107952

A_14_P138398

A_23_P210224

A_23_P401691

A_33_P3222183

GE62697

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0007165

GO:0007399

GO:0007411

GO:0008017

GO:0008092

GO:0016787

GO:0016810

GO:0023052

GO:0030154

GO:0030182

GO:0030425

GO:0032991

GO:0043025

GO:0048856

GO:0050774

HMNXSV003047258

Hs.299315.0.S3_3p_at

ILMN_1804509

PH_hs_0015441

TC02000156.hg

g12804042_3p_a_at

Participates

as a member of

Other forms of this molecule

p-Y-DPYSL5 [cytosol]

DPYSL5 [cytosol]

Inferred To

phospho-dpysl5 [cytosol] (Xenopus tropicalis)

phospho-Dpysl5 [cytosol] (Mus musculus)

phospho-Dpysl5 [cytosol] (Rattus norvegicus)

phospho-p-S534-DPYSL5 [cytosol] (Caenorhabditis elegans)

phospho-p-S534-DPYSL5 [cytosol] (Canis familiaris)

phospho-p-S534-DPYSL5 [cytosol] (Danio rerio)

phospho-p-S534-DPYSL5 [cytosol] (Gallus gallus)

phospho-unc-33 [cytosol] (Caenorhabditis elegans)

phospho-DPYSL5 [cytosol] (Bos taurus)

phospho-DPYSL5 [cytosol] (Sus scrofa)

Homologues of p-S534-DPYSL5 [cytosol] (Caenorhabditis elegans)

phospho-CRMP [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 534

Coordinate

534

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001240653.1, NP_001240652.1, NP_064519.2

OpenTargets

ENSG00000157851

HPA

ENSG00000157851-DPYSL5

GeneCards

Q9BPU6

Ensembl

ENSP00000288699, ENSP00000481305, ENSG00000157851, ENSP00000385549, ENST00000614712, ENST00000401478, ENST00000288699

PRO

Q9BPU6

Pharos - Targets

Q9BPU6

PDB

4B91, 4B92, 4B90

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3