Activation of Ca impermeable AMPA receptors

Stable Identifier
R-HSA-399711
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Each AMPA receptor subunit binds one glutamate molecule in the ligand binding site in the N terminus. Each receptor is capable of binding four glutamate molecules however, channel opens when two sites are occupied by the ligand and the current increases with increased ligand binding. Ca impermeable AMPA receptors containing GluR2 subunit conduct Na currents upon activation by either glutamate binding or agonist, AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding. The Na currents mainly lead to depolarization of the membrane leading to activation of voltage gated channels such as NMDA receptors that require both agonist binding and depolarization for their activation.

Literature References
PubMed ID Title Journal Year
17409242 Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family

Kott, S, Werner, M, K├Ârber, C, Hollmann, M

J Neurosci 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
excitatory extracellular ligand-gated ion channel activity of Ca impermeable AMPA receptor ligand complex [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created