G-protein beta:gamma signalling

Stable Identifier
R-HSA-397795
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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G-protein beta:gamma signalling
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The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.
Literature References
PubMed ID Title Journal Year
18834311 The Role of Gbetagamma Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes

Robitaille, M, Dupré, DJ, Rebois, RV, Hébert, TE

Annu Rev Pharmacol Toxicol 2008
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Orthologous Events
G-protein beta:gamma signalling (Bos taurus)
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G-protein beta:gamma signalling (Danio rerio)
G-protein beta:gamma signalling (Dictyostelium discoideum)
G-protein beta:gamma signalling (Drosophila melanogaster)
G-protein beta:gamma signalling (Gallus gallus)
G-protein beta:gamma signalling (Mus musculus)
G-protein beta:gamma signalling (Rattus norvegicus)
G-protein beta:gamma signalling (Saccharomyces cerevisiae)
G-protein beta:gamma signalling (Schizosaccharomyces pombe)
G-protein beta:gamma signalling (Sus scrofa)
G-protein beta:gamma signalling (Xenopus tropicalis)
Authored
Jupe, S  (2009-03-13)
Reviewed
Akkerman, JW  (2009-06-03)
Created
Jupe, S  (2009-03-13)
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