Thrombin-activated PARs binds G-protein Gq

Stable Identifier
R-HSA-396996
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Thrombin-activated PARs binds G-protein Gq
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Thrombin signalling through PARs is mediated in part through the Gq family of G-proteins. Gq knockout mice have defective platelet responses to thrombin (as well as to ADP and thromboxane).
Literature References
PubMed ID Title Journal Year
8982657 Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells

Ogino, Y, Tanaka, K, Shimizu, N

Eur J Pharmacol 1996
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Orthologous Events
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Thrombin-activated PARs binds G-protein Gq (Canis familiaris)
Thrombin-activated PARs binds G-protein Gq (Gallus gallus)
Thrombin-activated PARs binds G-protein Gq (Mus musculus)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-03-11)
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