DAAM1 recruits PFN1

Stable Identifier
R-HSA-3965450
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The FH1 domain of DAAM1 recruits Profilin1 (PFN1) to the DVL:DAAM1 complex, and DAAM1 and PFN1 colocalize at stress fibers in response to WNT signaling (Sato et al, 2006). In addition to binding to FH domains, Profilin proteins bind to monomeric actin and in this way serve as a source of actin for polymerization of unbranched actin chains (Birbach, 2008; Goode and Eck, 2007). Depletion of PFN1 inhibits stress fiber formation in response to WNT signaling but does not affect DAAM1-mediated RHO A activation. In vivo, PFN1 is required downstream of DAAM1 for blastopore closure in Xenopus (Sato et al, 2006). In another study, PFN2 was also identified as an FH1 domain-interacting partner of DAAM1. The roles of PFN1 and PFN2 appear to be non-overlapping, however, as PFN2 is not required for blastopore closure in Xenopus but instead contributes to convergent extension (Khadka et al, 2009).

Literature References
PubMed ID Title Journal Year
19523939 Non-redundant roles for Profilin2 and Profilin1 during vertebrate gastrulation

Khadka, DK, Liu, W, Habas, R

Dev. Biol. 2009
17373907 Mechanism and function of formins in the control of actin assembly

Goode, BL, Eck, MJ

Annu. Rev. Biochem. 2007
18798527 Profilin, a multi-modal regulator of neuronal plasticity

Birbach, A

Bioessays 2008
17021034 Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation

Sato, A, Khadka, DK, Liu, W, Bharti, R, Runnels, LW, Dawid, IB, Habas, R

Development 2006
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