Studies with FZD receptors in zebrafish, Xenopus and mouse teratocarcinoma cells suggest that G-proteins are involved in signal transduction downstream of WNT5A/WNT11 signaling. Disrupting the function of G-protein alpha 0 and t2 subunits abrogates FZD-dependent calcium release and activation of potential downstream targets such as PKC, CaMK2 and calcineurin (Slusarski et al, 1997; Liu et al, 1999; Penzo-Mendez et al 2002; reviewed in Malbon et al, 2001; Angers and Moon, 2009)
Angers, S, Moon, RT
Corces, VG, Slusarski, DC, Moon, RT
Yang-Snyder, J, Liu, X, Liu, T, Moon, RT, Wang, H, Slusarski, DC, Malbon, CC
Wang, H, Malbon, CC, Moon, RT
Penzo-Mendèz, A, Riou, JF, Djiane, A, Umbhauer, M, Boucaut, JC
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