FZD recruits trimeric G-proteins

Stable Identifier
Reaction [binding]
Homo sapiens
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Studies with FZD receptors in zebrafish, Xenopus and mouse teratocarcinoma cells suggest that G-proteins are involved in signal transduction downstream of WNT5A/WNT11 signaling. Disrupting the function of G-protein alpha 0 and t2 subunits abrogates FZD-dependent calcium release and activation of potential downstream targets such as PKC, CaMK2 and calcineurin (Slusarski et al, 1997; Liu et al, 1999; Penzo-Mendez et al 2002; reviewed in Malbon et al, 2001; Angers and Moon, 2009)

Literature References
PubMed ID Title Journal Year
19536106 Proximal events in Wnt signal transduction

Angers, S, Moon, RT

Nat Rev Mol Cell Biol 2009
9389482 Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling

Corces, VG, Slusarski, DC, Moon, RT

Nature 1997
10588714 Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat

Yang-Snyder, J, Liu, X, Liu, T, Moon, RT, Wang, H, Slusarski, DC, Malbon, CC

Proc. Natl. Acad. Sci. U.S.A. 1999
11563835 Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance?

Wang, H, Malbon, CC, Moon, RT

Biochem. Biophys. Res. Commun. 2001
12729560 Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation

Penzo-Mend├Ęz, A, Riou, JF, Djiane, A, Umbhauer, M, Boucaut, JC

Dev. Biol. 2003
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