Studies with FZD receptors in zebrafish, Xenopus and mouse teratocarcinoma cells suggest that G-proteins are involved in signal transduction downstream of WNT5A/WNT11 signaling. Disrupting the function of G-protein alpha 0 and t2 subunits abrogates FZD-dependent calcium release and activation of potential downstream targets such as PKC, CaMK2 and calcineurin (Slusarski et al, 1997; Liu et al, 1999; Penzo-Mendez et al 2002; reviewed in Malbon et al, 2001; Angers and Moon, 2009)
Slusarski, DC, Corces, VG, Moon, RT
Angers, S, Moon, RT
Liu, X, Liu, T, Slusarski, DC, Yang-Snyder, J, Malbon, CC, Moon, RT, Wang, H
Malbon, CC, Wang, H, Moon, RT
Penzo-Mendèz, A, Umbhauer, M, Djiane, A, Boucaut, JC, Riou, JF
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