Reactome | FZD recruits trimeric G-proteins

FZD recruits trimeric G-proteins

Stable Identifier

R-HSA-3965441

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Studies with FZD receptors in zebrafish, Xenopus and mouse teratocarcinoma cells suggest that G-proteins are involved in signal transduction downstream of WNT5A/WNT11 signaling. Disrupting the function of G-protein alpha 0 and t2 subunits abrogates FZD-dependent calcium release and activation of potential downstream targets such as PKC, CaMK2 and calcineurin (Slusarski et al, 1997; Liu et al, 1999; Penzo-Mendez et al 2002; reviewed in Malbon et al, 2001; Angers and Moon, 2009)

Literature References

PubMed ID	Title	Journal	Year
19536106	Proximal events in Wnt signal transduction Angers, S, Moon, RT	Nat Rev Mol Cell Biol	2009
9389482	Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling Slusarski, DC, Corces, VG, Moon, RT	Nature	1997
10588714	Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat Liu, X, Liu, T, Slusarski, DC, Yang-Snyder, J, Malbon, CC, Moon, RT, Wang, H	Proc. Natl. Acad. Sci. U.S.A.	1999
11563835	Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance? Malbon, CC, Wang, H, Moon, RT	Biochem. Biophys. Res. Commun.	2001
12729560	Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation Penzo-Mendèz, A, Umbhauer, M, Djiane, A, Boucaut, JC, Riou, JF	Dev. Biol.	2003