MMP2,9 cleave EPHB

Stable Identifier
R-HSA-3928657
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
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MMP2,9 cleave EPHB
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Alternatively, the EPH:ephrin (EPH:EFN) interaction can be broken by proteolytic cleavage of the EPH receptors by matrix metalloproteinases (MMPs) and gamma-secretase. Ethell and his group showed that the EPHB2 receptor is cleaved by the secreted MMPs MMP-2 and MMP-9, and this cleavage is induced by EFNB:EPHB receptor interaction. EPHB2 receptor is initially cleaved within the fibronectin (FN) type III domain or between residues 543 and 544 (mouse EPHB2) at the cell surface by MMPs to produce a long fragment that is released to the extracellular space and a membrane bound C-terminal fragment (Ethell et al. 2007, Litterst et al. 2007).

Literature References
PubMed ID Title Journal Year
18713744 Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion

Lin, KT, Sloniowski, S, Ethell, DW, Ethell, IM

J. Biol. Chem. 2008
17428795 Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor

Litterst, C, Georgakopoulos, A, Shioi, J, Ghersi, E, Wisniewski, T, Wang, R, Ludwig, A, Robakis, NK

J. Biol. Chem. 2007
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP2, MMP9 [extracellular region]
Physical Entity
MMP2, MMP9 [extracellular region]
Activity
serine-type endopeptidase activity (0004252)
Orthologous Events
MMP2,9 cleave EPHB (Bos taurus)
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MMP2,9 cleave EPHB (Gallus gallus)
MMP2,9 cleave EPHB (Mus musculus)
MMP2,9 cleave EPHB (Rattus norvegicus)
MMP2,9 cleave EPHB (Sus scrofa)
MMP2,9 cleave EPHB (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-22)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)