EPHB2-C-terminal fragment1 (CTF1) is subsequently cleaved within the transmembrane domain between residues 569 and 570 (mouse EPHB2) by gamma-secretase to release a shorter cytosolic fragment containing 425 C-terminal amino acids. The EPHB2 cleavage products EPHB2-CTF1 and EPHB2-CTF2 may enhance the duration of full length EPHB2 phosphorylation. These fragments lack the ephrin (EFN)-binding domain, but retain the entire cytoplasmic portion of the receptor, and may sequester phosphatases from full-length EPHB2 receptor, thus preventing its dephosphorylation (Litterst et al. 2007).
Litterst, C, Georgakopoulos, A, Shioi, J, Ghersi, E, Wisniewski, T, Wang, R, Ludwig, A, Robakis, NK
Georgakopoulos, A, Litterst, C, Ghersi, E, Baki, L, Xu, C, Serban, G, Robakis, NK
Lin, KT, Sloniowski, S, Ethell, DW, Ethell, IM
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