EPHB2-C-terminal fragment1 (CTF1) is subsequently cleaved within the transmembrane domain between residues 569 and 570 (mouse EPHB2) by gamma-secretase to release a shorter cytosolic fragment containing 425 C-terminal amino acids. The EPHB2 cleavage products EPHB2-CTF1 and EPHB2-CTF2 may enhance the duration of full length EPHB2 phosphorylation. These fragments lack the ephrin (EFN)-binding domain, but retain the entire cytoplasmic portion of the receptor, and may sequester phosphatases from full-length EPHB2 receptor, thus preventing its dephosphorylation (Litterst et al. 2007).
Xu, C, Baki, L, Serban, G, Litterst, C, Georgakopoulos, A, Robakis, NK, Ghersi, E
Wisniewski, T, Litterst, C, Ludwig, A, Wang, R, Georgakopoulos, A, Robakis, NK, Shioi, J, Ghersi, E
Ethell, DW, Sloniowski, S, Ethell, IM, Lin, KT
endopeptidase activity of gamma-secretase complex [plasma membrane]
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