gamma-secretase cleaves EPHB2

Stable Identifier
R-HSA-3928656
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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gamma-secretase cleaves EPHB2
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EPHB2-C-terminal fragment1 (CTF1) is subsequently cleaved within the transmembrane domain between residues 569 and 570 (mouse EPHB2) by gamma-secretase to release a shorter cytosolic fragment containing 425 C-terminal amino acids. The EPHB2 cleavage products EPHB2-CTF1 and EPHB2-CTF2 may enhance the duration of full length EPHB2 phosphorylation. These fragments lack the ephrin (EFN)-binding domain, but retain the entire cytoplasmic portion of the receptor, and may sequester phosphatases from full-length EPHB2 receptor, thus preventing its dephosphorylation (Litterst et al. 2007).

Literature References
PubMed ID Title Journal Year
17428795 Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor

Litterst, C, Georgakopoulos, A, Shioi, J, Ghersi, E, Wisniewski, T, Wang, R, Ludwig, A, Robakis, NK

J. Biol. Chem. 2007
16511561 Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

Georgakopoulos, A, Litterst, C, Ghersi, E, Baki, L, Xu, C, Serban, G, Robakis, NK

EMBO J. 2006
18713744 Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion

Lin, KT, Sloniowski, S, Ethell, DW, Ethell, IM

J. Biol. Chem. 2008
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
gamma-secretase complex [plasma membrane]
Activity
endopeptidase activity (0004175)
Orthologous Events
gamma-secretase cleaves EPHB2 (Bos taurus)
gamma-secretase cleaves EPHB2 (Canis familiaris)
gamma-secretase cleaves EPHB2 (Danio rerio)
gamma-secretase cleaves EPHB2 (Gallus gallus)
gamma-secretase cleaves EPHB2 (Mus musculus)
gamma-secretase cleaves EPHB2 (Rattus norvegicus)
gamma-secretase cleaves EPHB2 (Sus scrofa)
gamma-secretase cleaves EPHB2 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-23)