NGEF exchanges GTP for GDP on RHOA

Stable Identifier
R-HSA-3928651
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The tyrosine phosphorylation of ephexin1 (NGEF)/Ephexin-1 enhances its exchange activity and specifically activates inactive RHOA:GDP to active RHOA:GTP. Activated RHOA regulates myosin II activity in neurons through Rho-associated kinase (ROCK), and leads to rapid growth cone collapse, neurite retraction, or neurite growth inhibition in axons. Through this repulsive mechanism EPH receptors and ephrins (EFNs) guide retinal axons to their targets in the visual centres in the brain (Sahin et al. 2005).

Literature References
PubMed ID Title Journal Year
10769020 Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

Wahl, S, Barth, H, Ciossek, T, Aktories, K, Mueller, BK

J. Cell Biol. 2000
15848799 Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse

Sahin, M, Greer, PL, Lin, MZ, Poucher, H, Eberhart, J, Schmidt, S, Wright, TM, Shamah, SM, O'connell, S, Cowan, CW, Hu, L, Goldberg, JL, Debant, A, Corfas, G, Krull, CE, Greenberg, ME

Neuron 2005
11179879 Rho GTPases in growth cone guidance

Dickson, BJ

Curr. Opin. Neurobiol. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created