EPHAs bind EFNAs

Stable Identifier
R-HSA-3928646
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Ephrin-A ligands interacts with EPHA receptors
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The first step in the initiation of EPH-mediated signaling is the high affinity interaction between EPH receptors and ephrin (EFN) ligands of the same subclass located on closely opposed cell surfaces. Membrane bound EPHs bind to EFNs with high affinity and this results in the development of close contacts between the cells. This association between EPHs and EFNs on opposing cells is called trans-interaction and this close contact is required for signaling. This high affinity interaction usually result in contact-mediated repulsion. With some exceptions, the EPH receptor A-subclass (EPHA1-A8, A10) bind to the A-class ephrins (EFNA1-A4, A6). EPH and EFN initially form a 1:1 high affinity heterodimer, where ephrin inserts its extended loop into a channel at the surface of the receptor (Himanen et al. 2007, Himanen & Nikolov 2003, Himanen et al. 2001).

Literature References
PubMed ID Title Journal Year
11780069 Crystal structure of an Eph receptor-ephrin complex

Himanen, JP, Rajashankar, KR, Lackmann, M, Cowan, CA, Henkemeyer, M, Nikolov, DB

Nature 2001
12495863 Eph signaling: a structural view

Himanen, JP, Nikolov, DB

Trends Neurosci. 2003
17928214 Cell-cell signaling via Eph receptors and ephrins

Himanen, JP, Saha, N, Nikolov, DB

Curr. Opin. Cell Biol. 2007
19525919 Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex

Himanen, JP, Goldgur, Y, Miao, H, Myshkin, E, Guo, H, Buck, M, Nguyen, M, Rajashankar, KR, Wang, B, Nikolov, DB

EMBO Rep. 2009
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