bPIX exchanges GTP for GDP on RAC, activating it

Stable Identifier
R-HSA-3928633
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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p-21-activated kinase (PAK) interacting exchange factor (beta-PIX, bPIX aka ARHGEF7) a Rac GEF localised at the dendritic spines, activates Rac by exchanging GDP for GTP.
Literature References
PubMed ID Title Journal Year
12695502 Synapse formation is regulated by the signaling adaptor GIT1

Webb, DJ, Zhang, H, Horwitz, AF, Asmussen, H

J. Cell Biol. 2003
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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