EPHB phosphorylates TIAM1

Stable Identifier
R-HSA-3928627
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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EPHB phosphorylates TIAM1
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Once recruited to the EPHB:NMDAR complex, T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is phosphorylated on tyrosine 829 by either EPHB or a kinase that associates with activated EPHB. TIAM1 may then activate Rac1, leading to actin cytoskeletal remodelling required for spine development and morphogenesis (Tolias et al. 2007).
Literature References
PubMed ID Title Journal Year
17440041 The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development

Kane, CG, Greenberg, ME, Hu, L, Bikoff, JB, Tolias, KF, Tolias, CS

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane]

Physical Entity
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
EPHB phosphorylates TIAM1 (Caenorhabditis elegans)
EPHB phosphorylates TIAM1 (Canis familiaris)
EPHB phosphorylates TIAM1 (Drosophila melanogaster)
EPHB phosphorylates TIAM1 (Gallus gallus)
EPHB phosphorylates TIAM1 (Mus musculus)
EPHB phosphorylates TIAM1 (Rattus norvegicus)
EPHB phosphorylates TIAM1 (Sus scrofa)
EPHB phosphorylates TIAM1 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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