EPHBs bind EFNBs

Stable Identifier
Reaction [binding]
Homo sapiens
Ephrin-B ligands interacts with EPHB receptors
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The first step in the initiation of EPH-mediated signaling is the high affinity interaction between EPH receptors and ephrin (EFN) ligands of the same subclass located on closely opposed cell surfaces. Membrane bound EPHs bind to EFNs with high affinity and this results in the development of close contacts between the cells. This association between EPHs and EFNs on opposing cells is called trans-interaction and this close contact is required for signaling. This high affinity interaction usually result in contact-mediated repulsion. With some exceptions, B-type EPH receptors (EPHB1-B6) interact with the B-subclass ephrins (EFNB1-B3). EPH and EFN initially form a 1:1 high affinity heterodimer, where EFN inserts its extended loop into a channel at the surface of the receptor (Himanen et al. 2007, Himanen & Nikolov 2003, Himanen et al. 2001).

Literature References
PubMed ID Title Journal Year
12495863 Eph signaling: a structural view

Himanen, JP, Nikolov, DB

Trends Neurosci. 2003
11780069 Crystal structure of an Eph receptor-ephrin complex

Lackmann, M, Henkemeyer, M, Himanen, JP, Rajashankar, KR, Nikolov, DB, Cowan, CA

Nature 2001
17928214 Cell-cell signaling via Eph receptors and ephrins

Saha, N, Himanen, JP, Nikolov, DB

Curr. Opin. Cell Biol. 2007
Orthologous Events
Cite Us!