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EPHB2 binds KALRN
Stable Identifier
R-HSA-3928617
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
EPHB2 binds KALRN (Homo sapiens)
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Penzes et al. showed that the Kalirin-Rac1-PAK pathway is another signaling cascade downstream of EPHB2 that leads to dendritic spine maturation (Penzes et al. 2003). Kalirin (KALRN) is a Rac-GEF expressed postnatally in neurons and localised to the postsynaptic densities at excitatory synapses, where it participates in the formation and maintenance of dendritic spines. In young hippocampal pyramidal neurons, KALRN links trans-synaptic signaling through ephrinB (EFNB) and EPHB receptors to spine formation and maturation. Upon EFNB activation, KALRN binds EPHB2 and translocates to the postsynaptic membrane.
Literature References
PubMed ID
Title
Journal
Year
12546821
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin
Penzes, P
,
Eipper, BA
,
Schiller, MR
,
Huganir, RL
,
Chernoff, J
,
Beeser, A
,
Mains, RE
Neuron
2003
Participants
Input
KALRN [cytosol]
(Homo sapiens)
p-EPHB:EFNB oligomers [plasma membrane]
(Homo sapiens)
Output
EFNBs:p-EPHBs:KALRN [plasma membrane]
(Homo sapiens)
Participates
as an event of
EPHB-mediated forward signaling (Homo sapiens)
Orthologous Events
EPHB2 binds KALRN (Caenorhabditis elegans)
EPHB2 binds KALRN (Canis familiaris)
EPHB2 binds KALRN (Drosophila melanogaster)
EPHB2 binds KALRN (Gallus gallus)
EPHB2 binds KALRN (Mus musculus)
EPHB2 binds KALRN (Rattus norvegicus)
Authored
Garapati, P V (2013-07-23)
Reviewed
Ip, NY (2014-05-19)
Created
Garapati, P V (2013-07-22)
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